南蛇藤果实中的倍半萜酯类化合物。

Sesquiterpene esters from the fruits of Celastrus orbiculatus.

作者信息

Guo Yuan Qiang, Li Xian, Xu Jing, Li Ning, Meng Da Li, Wang Jin Hui

机构信息

Research Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China.

出版信息

Chem Pharm Bull (Tokyo). 2004 Sep;52(9):1134-6. doi: 10.1248/cpb.52.1134.

DOI:10.1248/cpb.52.1134

PMID:15340205

Abstract

Three new beta-dihydroagarofuran sesquiterpene esters, 6 alpha-acetoxy-9 beta-benzoyloxy-1 beta-cinnamoyloxy-8 beta-butanoyloxy-beta-dihydroagarofuran (1), 6 alpha-acetoxy-9 beta-benzoyloxy-1 beta-cinnamoyloxy-8 beta-(2-methylbutanoyloxy)-beta-dihydroagarofuran (2), and 6 alpha-acetoxy-1 beta,8 beta-dibenzoyloxy-9 beta-hydroxy-beta-dihydroagarofuran (6), together with three known compounds (3-5) were isolated from the fruits of Celastrus orbiculatus THUNB. Their structures were elucidated on the basis of spectroscopic methods. Compound 4 showed moderate activity in inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells with an IC(50) value of 43.7 microM.

摘要

从南蛇藤（Celastrus orbiculatus THUNB.）果实中分离得到了三种新的β-二氢沉香呋喃倍半萜酯，即6α-乙酰氧基-9β-苯甲酰氧基-1β-肉桂酰氧基-8β-丁酰氧基-β-二氢沉香呋喃（1）、6α-乙酰氧基-9β-苯甲酰氧基-1β-肉桂酰氧基-8β-（2-甲基丁酰氧基）-β-二氢沉香呋喃（2）和6α-乙酰氧基-1β,8β-二苯甲酰氧基-9β-羟基-β-二氢沉香呋喃（6），以及三种已知化合物（3 - 5）。通过光谱方法对它们的结构进行了鉴定。化合物4在抑制小鼠巨噬细胞RAW264.7细胞中脂多糖诱导的一氧化氮产生方面表现出中等活性，IC(50)值为43.7 microM。