Nestor Paul G, Kubicki Marek, Spencer Kevin M, Niznikiewicz Margaret, McCarley Robert W, Shenton Martha E
Department of Psychology, University of Massachusetts, Boston, MA 02125-3393, USA.
Schizophr Res. 2007 Feb;90(1-3):308-15. doi: 10.1016/j.schres.2006.10.005. Epub 2006 Dec 5.
Thirty patients with chronic schizophrenia and 30 age-matched controls performed the Attention Network Test (ANT). A subset of the patient group (n=18) also had available magnetic resonance diffusion tensor imaging (DTI) measures of the cingulum bundle (CB) fractional anisotropy and volume. The patients showed a significantly different pattern of ANT performance, characterized primarily by decreased alerting efficiency. In addition, left CB fractional anisotropy correlated significantly with orienting of attention. Smaller right CB volume also correlated with reduced alertness, but not when covarying for medication and illness duration.
30名慢性精神分裂症患者和30名年龄匹配的对照组进行了注意力网络测试（ANT）。患者组的一个子集（n = 18）也有扣带束（CB）分数各向异性和体积的磁共振扩散张量成像（DTI）测量值。患者表现出明显不同的ANT表现模式，主要特征是警觉效率降低。此外，左侧CB分数各向异性与注意力定向显著相关。右侧CB体积较小也与警觉性降低相关，但在对药物和病程进行协变量调整后则不相关。
