Shorrock K, Austen B M, Hermon-Taylor J
Department of Surgery, St. Georges Hospital Medical School, London, England.
Pancreas. 1991 Jul;6(4):404-6. doi: 10.1097/00006676-199107000-00005.
Acute pancreatic oedema with hyperamylasaemia was induced in mice by subcutaneous administration of cholecystokinin octapeptide (CCK8). Comparison with effect of caerulein showed that cholecystokinin is less potent in vivo. To investigate the observed difference in response, threonine3 CCK8 and methionine5 caerulein were synthesised and evaluated. Comparison of these peptides suggests that difference in bioactivity is related to possession of extra N-terminal residues rather than substitution of threonine for methionine.
通过皮下注射八肽胆囊收缩素（CCK8）在小鼠中诱导出急性胰腺水肿伴高淀粉酶血症。与蛙皮素的作用比较表明，胆囊收缩素在体内的效力较低。为了研究观察到的反应差异，合成并评估了苏氨酸3 CCK8和蛋氨酸5蛙皮素。这些肽的比较表明，生物活性的差异与额外N端残基的存在有关，而不是苏氨酸取代蛋氨酸。
