与单独使用CHX和安慰剂相比，应用CHX/F漱口水后龋损釉质病变的再矿化情况。

Remineralisation of carious enamel lesions after application of a CHX/F-mouthrinse compared with sole CHX- and placebo-application.

作者信息

Altenburger Markus Jörg, Klasser Manfred, Schirrmeister Jörg Fabian, Hellwig Elmar

机构信息

Department of Operative Dentistry and Periodontology, Albert-Ludwigs-University of Freiburg, Germany.

出版信息

Oral Health Prev Dent. 2006;4(4):255-63.

PMID:17153647

Abstract

PURPOSE

The purpose of this cross-over, double-blind, placebo-controlled, randomised in situ study was to evaluate the remineralisation of demineralised enamel specimens using a CHX/NaF mouthrinse in comparison with a CHX- and a placebo-mouthrinse.

MATERIALS AND METHODS

Twenty-four volunteers received intraoral appliances with mounted demineralised enamel specimens. They rinsed their mouths twice a day (10 ml for 1 minute) with the respective preparation. After 14 days, the in situ mineral gain and fluoride uptake were determined.

RESULTS

Mineral gain was significantly higher after using CHX/F mouthrinse (358.4 +/- 372.1 Vol.% X microm) compared with CHX (95.6+/-192.2 Vol.% X microm) and placebo treatment (80.8 +/- 159.6 Vol.% x microm). Moreover, CHX/F treatment (2751.1+/-1494.9 microg/cm(3)) resulted in a significantly higher fluoride uptake compared with CHX- (83.8+/-94.0 microg/cm(3)) and placebo- (136.6+/-137.3 microg/cm(3)) mouthrinses.

CONCLUSION

The in situ study approves that using a CHX/F mouthrinse supports the remineralisation of initial carious lesions.

摘要

目的

本交叉、双盲、安慰剂对照、随机原位研究的目的是评估使用洗必泰/氟化钠漱口水与洗必泰漱口水和安慰剂漱口水相比，对脱矿釉质标本的再矿化作用。

材料与方法

24名志愿者佩戴装有脱矿釉质标本的口腔矫治器。他们每天用相应制剂漱口两次（10毫升，持续1分钟）。14天后，测定原位矿物质增加量和氟摄取量。

结果

与洗必泰漱口水（95.6±192.2体积%×微米）和安慰剂治疗（80.8±159.6体积%×微米）相比，使用洗必泰/氟漱口水后矿物质增加量显著更高（358.4±372.1体积%×微米）。此外，与洗必泰漱口水（83.8±94.0微克/立方厘米）和安慰剂漱口水（136.6±137.3微克/立方厘米）相比，洗必泰/氟治疗（2751.1±1494.9微克/立方厘米）导致氟摄取量显著更高。