Zero D T, Zhang J Z, Harper D S, Wu M, Kelly S, Waskow J, Hoffman M
Department of Preventive and Community Dentistry, Indiana University School of Dentistry, Indianapolis 46202, USA.
J Am Dent Assoc. 2004 Feb;135(2):231-7. doi: 10.14219/jada.archive.2004.0157.
The authors conducted a two-week clinical study to determine the remineralizing effect of an experimental mouthrinse containing both fluoride and essential oils in an intraoral caries test model.
The study used an observer-blinded, randomized, controlled, 3 x 3 crossover design. The authors enrolled in the study 153 subjects, each of whom had a mandibular removable partial denture. Two partially demineralized human enamel specimens were mounted on each subject's removable partial denture. Subjects used either a fluoride mouthrinse with essential oils (the test mouthrinse), a fluoride nonessential oils mouthrinse (the positive control) or an essential oil nonfluoride mouthrinse (the negative control) twice daily for 14 days. The researchers assessed specimens for mineral content change and fluoride uptake using surface microhardness, or SMH, testing and enamel fluoride analysis, respectively.
Of the 153 subjects enrolled in the study, 125 subjects were evaluable at the study endpoint. The results after two weeks showed that percentage of SMH recovery was 42 percent in the test group, 36 percent in the positive control group and 16 percent in the negative control group. The fluoride uptake was 19 micrograms per square centimeter, 16 microg/cm2 and 3 microg/cm2 for the test mouthrinse, positive control and negative control groups, respectively. In terms of both percentage of SMH and fluoride uptake, the test mouthrinse and positive control mouthrinse were statistically higher than the negative control mouthrinse, and the test mouthrinse was "at least as good as" the positive control mouthrinse.
This study provides evidence that an essential oil mouthrinse with 100 parts per million fluoride is effective in promoting enamel remineralization and fluoride uptake.
The combination of fluoride and essential oils in a mouthrinse may provide anticaries efficacy, in addition to essential oils' previously established antigingivitis efficacy.
作者进行了一项为期两周的临床研究，以确定在口腔内龋齿测试模型中，一种含氟和精油的实验性漱口水的再矿化效果。
该研究采用观察者盲法、随机、对照、3×3交叉设计。作者招募了153名受试者，每名受试者均佩戴下颌可摘局部义齿。在每名受试者的可摘局部义齿上安装两块部分脱矿的人牙釉质标本。受试者每天使用含精油的氟化物漱口水（测试漱口水）、不含精油的氟化物漱口水（阳性对照）或不含氟化物的精油漱口水（阴性对照）两次，持续14天。研究人员分别使用表面显微硬度测试（SMH）和牙釉质氟分析评估标本的矿物质含量变化和氟摄取情况。
在该研究招募的153名受试者中，有125名受试者在研究终点时可进行评估。两周后的结果显示，测试组的SMH恢复百分比为42%，阳性对照组为36%，阴性对照组为16%。测试漱口水组、阳性对照组和阴性对照组的氟摄取量分别为每平方厘米19微克、16微克/平方厘米和3微克/平方厘米。就SMH百分比和氟摄取量而言，测试漱口水和阳性对照漱口水在统计学上均高于阴性对照漱口水，且测试漱口水“至少与”阳性对照漱口水效果相当。
本研究提供了证据，表明含百万分之一百氟化物的精油漱口水在促进牙釉质再矿化和氟摄取方面是有效的。
漱口中氟化物和精油的组合除了具有精油先前已确定抗牙龈炎功效外，还可能具有防龋功效
