Neu Josef, Hauser Nicholas, Douglas-Escobar Martha
Department of Pediatrics, University of Florida, College of Medicine, Division of Neurology, Box J296, 1600 SW Archer Road, Room HD 513, Gainesville, FL 32610-0296, USA.
Semin Fetal Neonatal Med. 2007 Feb;12(1):78-86. doi: 10.1016/j.siny.2006.10.009. Epub 2006 Dec 5.
The early postnatal interplay between nutrition, growth patterns, and metabolic and epigenetic phenomena is crucial in determining subsequent health; health that extends through the lifetime of the individual and very likely even into subsequent generations. Recent research in the area of postnatal nutrition and its relationship to adult health, with an emphasis on the appropriate-for-gestational-age infant who is born prematurely and who undergoes growth delays, is presented. Select studies in animals, pertinent to understanding the mechanisms of how early postnatal under- and overnutrition might affect adult health and propagate to subsequent generations, are reviewed. Scientifically based approaches to administering postnatal nutrition designed to improve outcomes and areas where future investigations are needed are presented.
出生后早期营养、生长模式与代谢及表观遗传现象之间的相互作用,对于决定后续健康状况至关重要;这种健康状况会贯穿个体一生,甚至很可能延续至后代。本文介绍了产后营养领域及其与成人健康关系的最新研究,重点关注早产且生长发育迟缓的适于胎龄儿。回顾了一些动物研究,这些研究有助于理解出生后早期营养不足和营养过剩如何影响成人健康并遗传给后代的机制。还介绍了旨在改善结局的产后营养科学给药方法以及未来需要进一步研究的领域。