Danesh-Meyer Helen V, Carroll Stuart C, Ku Judy Y F, Hsiang John, Gaskin Brent, Gamble Greg G, Savino Peter J
Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Arch Ophthalmol. 2006 Dec;124(12):1720-6. doi: 10.1001/archopht.124.12.1720.
To evaluate the relationship between retinal nerve fiber layer (RNFL) measurement with scanning laser polarimetry (SLP) and standard automated perimetry (SAP) in nonarteritic anterior ischemic optic neuropathy (NAION).
In this prospective observational case series, all subjects (28 eyes with NAION) underwent SAP and SLP. The RNFL retardation measurements and visual field test points were grouped into 6 corresponding sectors. The contralateral uninvolved eye was used as control. The relationship between RNFL retardation and SAP was evaluated with the Spearman nonparametric technique and linear regression analysis. The main outcome measure was correlation of SLP RNFL parameters and SAP.
Global and sectoral SLP parameters showed a significant difference in affected eyes compared with controls. The strongest correlations were seen between mean deviation and number (r = -0.524; P = .004), ellipse modulation (r = 0.5026; P = .006), and maximum modulation (r = 0.526; P = .004). Superior sectoral visual field indexes showed a strong correlation with inferior RNFL changes (r = 0.522; P<.008). Linear regression confirmed a strong relationship between the superior sectoral visual field indexes and the inferior RNFL.
Scanning laser polarimetry was able to identify structural changes of the RNFL globally and in the inferior SLP sector with functional loss in NAION.
评估扫描激光偏振仪（SLP）测量视网膜神经纤维层（RNFL）与标准自动视野计（SAP）在非动脉炎性前部缺血性视神经病变（NAION）中的关系。
在这个前瞻性观察性病例系列中，所有受试者（28只患有NAION的眼睛）均接受了SAP和SLP检查。将RNFL延迟测量值和视野测试点分为6个相应的扇形区域。对侧未受累眼用作对照。采用Spearman非参数技术和线性回归分析评估RNFL延迟与SAP之间的关系。主要观察指标是SLP RNFL参数与SAP的相关性。
与对照组相比，患眼的整体和扇形SLP参数存在显著差异。平均偏差与数量之间的相关性最强（r = -0.524；P = .004），椭圆调制（r = 0.5026；P = .006），以及最大调制（r = 0.526；P = .004）。上方扇形视野指数与下方RNFL变化呈强相关性（r = 0.522；P<.008）。线性回归证实上方扇形视野指数与下方RNFL之间存在密切关系。
扫描激光偏振仪能够识别NAION中RNFL的整体结构变化以及下方SLP扇形区域的功能丧失。
