酒精性胰腺炎的病理生理学：综述
Pathophysiology of alcoholic pancreatitis: an overview.
作者信息
Chowdhury Parimal, Gupta Priya
机构信息
Department of Physiology and Biophysics, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, Arkansas 72205, United States.
出版信息
World J Gastroenterol. 2006 Dec 14;12(46):7421-7. doi: 10.3748/wjg.v12.i46.7421.
Abstract
Use of alcohol is a worldwide habit regardless of socio-economic background. Heavy alcohol consumption is a potential risk factor for induction of pancreatitis. The current review cites the updated literature on the alcohol metabolism, its effects on gastrointestinal and pancreatic function and in causing pancreatic injury, genetic predisposition of alcohol induced pancreatitis. Reports describing prospective mechanisms of action of alcohol activating the signal transduction pathways, induction of oxidative stress parameters through the development of animal models are being presented.
摘要
无论社会经济背景如何，饮酒都是一种全球范围内的习惯。大量饮酒是诱发胰腺炎的一个潜在风险因素。本综述引用了关于酒精代谢、其对胃肠和胰腺功能的影响以及导致胰腺损伤的最新文献，以及酒精性胰腺炎的遗传易感性。还介绍了描述酒精激活信号转导途径的前瞻性作用机制、通过动物模型的建立诱导氧化应激参数的报告。
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