南非西开普省由一株北京菌株引起的耐药结核病疫情。
An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the western Cape, South Africa.
作者信息
Johnson R, Warren R, Strauss O J, Jordaan A M, Falmer A A, Beyers N, Schaaf H S, Murray M, Cloete K, van Helden P D, Victor T C
机构信息
Department of Science and Technology, Faculty of Health Science, Stellenbosch University, Tygerberg, South Africa.
出版信息
Int J Tuberc Lung Dis. 2006 Dec;10(12):1412-4.
During October 2005, four children in a school in Cape Town were identified with multidrug-resistant tuberculosis (MDR-TB). Genetic analysis confirmed that these isolates belonged to a single cluster (Beijing cluster 220) and that all harboured a -15 inhA(C-T) promoter mutation demonstrating transmission. Genetic analysis of isolates cultured from patients from the Boland-Overberg-South Cape-Karoo and Cape Town regions showed that 28% (58/209) of patients infected with a Beijing strain had the cluster 220 genotypes and that all harboured the same -15 inhA(C-T) promoter mutation. The presence of these transmissible MDR-TB strains may pose a threat to the community, and rigorous infection control measures are needed to ensure the safety of those exposed.
2005年10月期间，开普敦一所学校的4名儿童被确诊患有耐多药结核病（MDR-TB）。基因分析证实，这些分离株属于单一菌群（北京菌群220），且所有分离株都携带 inhA（C-T）启动子 -15 突变，表明存在传播情况。对来自博兰-奥弗贝格-南开普-卡鲁地区和开普敦地区患者培养的分离株进行基因分析显示，感染北京菌株的患者中有28%（58/209）具有菌群220基因型，且所有患者都携带相同的 inhA（C-T）启动子 -15 突变。这些可传播的耐多药结核病菌株的存在可能对社区构成威胁，因此需要采取严格的感染控制措施，以确保接触者的安全。
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