Shen Jianping, Liu Musang, Zhang Jianhua, Su Wenyi, Ding Guoxing
Department for Leprosy Control, Institute of Dermatology, CAMS, Nanjing, Jiangsu, China.
Lepr Rev. 2006 Sep;77(3):219-24.
This study investigates the relapse rate among multibacillary leprosy patients treated with 24 months of MDT in south west China. A retrospective relapse survey was conducted in the southwest of China. A detailed questionnaire was designed to collect the data on relapse among MB patients who completed 2 years of the WHO/MB regimen, from 1989 to 2000. The data about 2517 multibacillary leprosy patients in 27 counties in the southwest of China were collected. Among 2517 MB patients, 235 patients died or were lost to follow-up and 2374 were followed up for more than 3 years after completion of MDT. The total duration of follow-up was 20,825 person-years, with a mean duration of 8.27 years per patient. Five patients with relapse were identified with an accumulated relapse rate of 0.21/1000 person-years. Their initial BIs ranged from 1.8 to 5. The patients with relapse occurred 48-158 months after the completion of MDT. The relapse rate of MB patients treated with 24 months of the WHO/MB regimen was observed to be very low after long-term follow-up.
本研究调查了在中国西南部接受24个月多药联合化疗的多菌型麻风病患者的复发率。在中国西南部进行了一项回顾性复发调查。设计了一份详细问卷，以收集1989年至2000年期间完成2年世界卫生组织/多菌型治疗方案的多菌型患者的复发数据。收集了中国西南部27个县2517例多菌型麻风病患者的数据。在2517例多菌型患者中，235例死亡或失访，2374例在完成多药联合化疗后接受了3年以上的随访。随访总时长为20825人年，每位患者的平均随访时长为8.27年。确定有5例复发患者，累积复发率为0.21/1000人年。他们最初的细菌指数范围为1.8至5。复发患者在完成多药联合化疗后48 - 158个月出现复发。长期随访后发现，接受24个月世界卫生组织/多菌型治疗方案治疗的多菌型患者复发率非常低。
