Grant J A, Alam R, Lett-Brown M A
Department of Internal Medicine, University of Texas Medical Branch, Galveston.
Int Arch Allergy Appl Immunol. 1991;94(1-4):141-3. doi: 10.1159/000235346.
Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be characterized. MNC also secrete a histamine release-inhibitory factor (HRIF), which is a highly specific inhibitor, because it antagonizes only HRF. IL-8 resembles the low-molecular-weight species of HRIF in terms of size and specificity.
外周血单个核细胞（MNC）在自发状态下以及受到刺激时会合成多种组胺释放因子（HRF）。一些已明确的细胞因子具有组胺释放活性，尤其是结缔组织活化肽III、中性粒细胞活化肽2和白细胞介素-3（IL-3）。至少还有两种HRF有待明确其特性。MNC还分泌一种组胺释放抑制因子（HRIF），它是一种高度特异性的抑制剂，因为它仅拮抗HRF。白细胞介素-8在大小和特异性方面与低分子量的HRIF相似。
