Sontag Bernd, Gerlitz Martin, Paululat Thomas, Rasser Hans-Falk, Grün-Wollny Iris, Hansske Friedrich G
BioFocus DPI GmbH, Waldhofer Str. 104, D-69123 Heidelberg, Germany.
J Antibiot (Tokyo). 2006 Oct;59(10):659-63. doi: 10.1038/ja.2006.88.
During a screening campaign for new antimicrobial and antifungal secondary metabolites from several thousand actinomycetes, a novel compound, isolated by activity guided fractionation, was oxachelin (1) from the new Streptomyces sp. GW9/1258. Oxachelin shows strong antibiotic activities against several fungi and Gram(+) bacteria. Additionally, oxachelin is a strong complexing ligand for Fe3+ (siderophore), possibly making it useful e.g. for iron excess diseases.
在对数千株放线菌产生的新型抗菌和抗真菌次生代谢产物进行筛选的过程中，通过活性导向分级分离法从新的链霉菌属GW9/1258中分离出一种新型化合物——氧杂菌素（1）。氧杂菌素对几种真菌和革兰氏阳性菌具有很强的抗菌活性。此外，氧杂菌素是一种针对Fe3+的强络合配体（铁载体），这可能使其在例如铁过量疾病方面具有应用价值。
