刺桐根中的六种新成分。

Six new constituents from the roots of Erythrina variegata.

作者信息

Tanaka Hitoshi, Hirata Miyuki, Etoh Hideo, Sako Magoichi, Sato Masaru, Murata Jin, Murata Hiroko, Darnaedi Dedy, Fukai Toshio

机构信息

Faculty of Pharmacy, Meijo University, Yagoto, Tempaku-ku, Nagoya 468-8503, Japan.

出版信息

Chem Biodivers. 2004 Jul;1(7):1101-8. doi: 10.1002/cbdv.200490082.

DOI:10.1002/cbdv.200490082

PMID:17191901

Abstract

Three new isoflavonoids, eryvarins M-O (1-3), two new 2-arylbenzofurans, eryvarins P and Q (4 and 5), and a new 3-aryl-2,3-dihydrobenzofuran, eryvarin R (6), together with three known compounds, were isolated from the roots of Erythrina variegata. The structures of these compounds were established by spectroscopic analysis. Eryvarin R (6) is an unusual 3-aryl-2,3-dihydrobenzofuran derivative with a formyl (CHO) group. Eryvarin Q (5) showed potent antibacterial activity against methicillin-resistant Staphylococcus aureus.

摘要

从刺桐根部分离得到了三种新的异黄酮类化合物刺桐黄素M - O（1 - 3）、两种新的2 - 芳基苯并呋喃刺桐黄素P和Q（4和5）以及一种新的3 - 芳基 - 2,3 - 二氢苯并呋喃刺桐黄素R（6），同时还分离出了三种已知化合物。这些化合物的结构通过光谱分析得以确定。刺桐黄素R（6）是一种带有甲酰基（CHO）的不寻常的3 - 芳基 - 2,3 - 二氢苯并呋喃衍生物。刺桐黄素Q（5）对耐甲氧西林金黄色葡萄球菌表现出强效抗菌活性。