Simmel Friedrich C, Dittmer Wendy U
Department of Physics and Center for Nanoscience, LMU Munich, Geschwister Scholl Platz 1, 80539 Munich, Germany.
Small. 2005 Mar;1(3):284-99. doi: 10.1002/smll.200400111.
The molecular recognition properties of DNA molecules combined with the distinct mechanical properties of single and double strands of DNA can be utilized for the construction of nanodevices, which can perform ever more tasks with possible applications ranging from nanoconstruction to intelligent drug delivery. With the help of DNA it is possible to construct machinelike devices that are capable of rotational motion, pulling and stretching, or even unidirectional motion. It is possible to devise autonomous nanodevices, to grab and release molecules, and also to perform simple information-processing tasks.
DNA分子的分子识别特性,结合单链和双链DNA独特的机械特性,可用于构建纳米器件,这些纳米器件能够执行越来越多的任务,其可能的应用范围从纳米结构到智能药物递送。借助DNA,可以构建能够进行旋转运动、拉伸和伸展甚至单向运动的机器状装置。可以设计出自主纳米器件,用于抓取和释放分子,还能执行简单的信息处理任务。