Lirani-Galvão Ana Paula, Jorgetti Vanda, da Silva Orivaldo Lopes
Bioengineering Department, University of São Paulo, São Paulo, Brazil.
Photomed Laser Surg. 2006 Dec;24(6):735-40. doi: 10.1089/pho.2006.24.735.
This study aimed to compare the consequences of low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (LIPUS) on bone repair.
Many studies have assessed the effects of LLLT and LIPUS on bone repair, but a comparison of them is rare.
Male Wistar rats (n = 48) with tibial bone osteotomy were used. One group had the osteotomized limb treated with LLLT (GaAlAs laser, 780 nm, 30 mW, 112.5 J/cm(2)) and the second group with LIPUS (1.5 MHz, 30 mW/cm(2)), both for 12 sessions (five times per week); a third group was the control. After 20 days, rats were sacrificed and had their tibias submitted to a bending test or histomorphometric analysis.
In the bending test, maximum load at failure of LLLT group was significantly higher (p < 0.05). Bone histomorphometry revealed a significant increase in osteoblast number and surface, and osteoid volume in the LLLT group, and a significant increase in eroded and osteoclast surfaces in the LIPUS group.
LIPUS enhanced bone repair by promoting bone resorption in the osteotomy area, while LLLT accelerated this process through bone formation.
本研究旨在比较低强度激光疗法（LLLT）和低强度脉冲超声（LIPUS）对骨修复的影响。
许多研究评估了LLLT和LIPUS对骨修复的作用，但对它们进行比较的研究较少。
使用雄性Wistar大鼠（n = 48）制作胫骨截骨模型。一组对截骨肢体采用LLLT治疗（GaAlAs激光，780 nm，30 mW，112.5 J/cm²），另一组采用LIPUS治疗（1.5 MHz，30 mW/cm²），均治疗12次（每周5次）；第三组为对照组。20天后，处死大鼠，对其胫骨进行弯曲试验或组织形态计量学分析。
在弯曲试验中，LLLT组的最大破坏载荷显著更高（p < 0.05）。骨组织形态计量学显示，LLLT组的成骨细胞数量、表面及类骨质体积显著增加，而LIPUS组的侵蚀表面和破骨细胞表面显著增加。
LIPUS通过促进截骨区域的骨吸收增强骨修复，而LLLT则通过骨形成加速这一过程。
