Edvardsen Kåre, Brustad Magritt, Engelsen Ola, Aksnes Lage
Institute for Community Medicine, University of Tromsø, Tromsø, Norway.
Photochem Photobiol Sci. 2007 Jan;6(1):57-62. doi: 10.1039/b613263d. Epub 2006 Nov 10.
Populations at high latitudes experience several winter months with insufficient UV solar radiation to induce a significant cutaneous production of vitamin D. This unique study was designed to pursue an in vivo threshold of UV radiation needed for cutaneous production of vitamin D to take place if only the face was exposed to UV radiation. The vitamin D status were measured by analyzing blood samples weekly from a study group of 15 subjects over a period of 2 months during late winter, when UV radiation can be expected to increase substantially from rising solar elevations. Statistical analysis showed no significant positive association between the mean UV radiation dose and the mean 25(OH)D (25-hydroxy vitamin D) for the group. On an individual basis, however, we found indications that subjects with very low initial concentration of 25(OH)D (<30 nmol l(-1)) seemed to respond to UV radiation as early as in the beginning of March. For other individuals diet seemed to be the dominant controlling factor for 25(OH)D levels.
高纬度地区的人群在冬季的几个月里,接受的紫外线太阳辐射不足,无法促使皮肤大量生成维生素D。这项独特的研究旨在探寻仅面部暴露于紫外线辐射时,皮肤生成维生素D所需的紫外线辐射体内阈值。在冬末为期2个月的时间里,每周对15名受试者的研究组进行血样分析,以测定维生素D状态,此时随着太阳高度升高,紫外线辐射预计会大幅增加。统计分析表明,该组的平均紫外线辐射剂量与平均25(OH)D(25-羟基维生素D)之间无显著正相关。然而,就个体而言,我们发现有迹象表明,初始25(OH)D浓度极低(<30 nmol l(-1))的受试者早在3月初似乎就对紫外线辐射有反应。对于其他个体,饮食似乎是25(OH)D水平的主要控制因素。