Peake Jonathan M, Nosaka Kazunori, Muthalib Makii, Suzuki Katsuhiko
Faculty of Human Sciences, Waseda University, Tokorozawa, Japan.
Exerc Immunol Rev. 2006;12:72-85.
We compared changes in markers of muscle damage and systemic inflammation after submaximal and maximal lengthening muscle contractions of the elbow flexors. Using a cross-over design, 10 healthy young men not involved in resistance training completed a submaximal trial (10 sets of 60 lengthening contractions at 10% maximum isometric strength, 1 min rest between sets), followed by a maximal trial (10 sets of three lengthening contractions at 100% maximum isometric strength, 3 min rest between sets). Lengthening contractions were performed on an isokinetic dynamometer. Opposite arms were used for the submaximal and maximal trials, and the trials were separated by a minimum of two weeks. Blood was sampled before, immediately after, 1 h, 3 h, and 1-4 d after each trial. Total leukocyte and neutrophil numbers, and the serum concentration of soluble tumor necrosis factor-alpha receptor 1 were elevated after both trials (P < 0.01), but there were no differences between the trials. Serum IL-6 concentration was elevated 3 h after the submaximal contractions (P < 0.01). The concentrations of serum tumor necrosis factor-alpha, IL-1 receptor antagonist, IL-10, granulocyte-colony stimulating factor and plasma C-reactive protein remained unchanged following both trials. Maximum isometric strength and range of motion decreased significantly (P < 0.001) after both trials, and were lower from 1-4 days after the maximal contractions compared to the submaximal contractions. Plasma myoglobin concentration and creatine kinase activity, muscle soreness and upper arm circumference all increased after both trials (P < 0.01), but were not significantly different between the trials. Therefore, there were no differences in markers of systemic inflammation, despite evidence of greater muscle damage following maximal versus submaximal lengthening contractions of the elbow flexors.
我们比较了肘关节屈肌次最大和最大程度的肌肉拉长收缩后肌肉损伤和全身炎症标志物的变化。采用交叉设计，10名未参与抗阻训练的健康年轻男性完成了次最大试验（10组，每组60次以最大等长力量10%进行的拉长收缩，组间休息1分钟），随后进行最大试验（10组，每组3次以最大等长力量100%进行的拉长收缩，组间休息3分钟）。在等速测力计上进行拉长收缩。次最大和最大试验使用对侧手臂，且两次试验间隔至少两周。每次试验前、试验后即刻、1小时、3小时以及1 - 4天后采集血液样本。两次试验后总白细胞和中性粒细胞数量以及可溶性肿瘤坏死因子-α受体1的血清浓度均升高（P < 0.01），但两次试验之间无差异。次最大收缩后3小时血清IL - 6浓度升高（P < 0.01）。两次试验后血清肿瘤坏死因子-α、IL - 1受体拮抗剂、IL - 10、粒细胞集落刺激因子浓度以及血浆C反应蛋白均未改变。两次试验后最大等长力量和关节活动范围均显著降低（P < 0.001），且与次最大收缩相比，最大收缩后1 - 4天更低。两次试验后血浆肌红蛋白浓度和肌酸激酶活性、肌肉酸痛以及上臂围均增加（P < 0.01），但两次试验之间无显著差异。因此，尽管有证据表明肘关节屈肌最大程度的拉长收缩比次最大程度的拉长收缩造成了更大的肌肉损伤，但全身炎症标志物并无差异。
