Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y
South China Institute of Botany, Chinese Academy of Sciences, Guangzhou, China.
J Med Food. 2006 Winter;9(4):451-8. doi: 10.1089/jmf.2006.9.451.
Epidemiological studies have shown that intake of tea catechins is associated with a lower risk of cardiovascular disease. The antioxidative activity of tea-derived catechins has been extensively studied. Reports have shown that green tea extract intake is associated with increased weight loss due to diet-induced thermogenesis, which is generally attributed to the catechin epigallocatechin gallate. That catechin-polyphenols are known to be capable of inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine) is a possible explanation for why the green tea extract is effective in stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis. Knowledge about thermogenesis-induced weight loss produced by green tea's epigallocatechin gallate and its ability to inhibit catechol-O-methyltransferase is important for health benefits and for prolonging the action of norepinephrine in the synaptic cleft.
流行病学研究表明，摄入茶儿茶素与较低的心血管疾病风险相关。茶源儿茶素的抗氧化活性已得到广泛研究。报告显示，摄入绿茶提取物与因饮食诱导产热导致的体重减轻增加有关，这通常归因于儿茶素表没食子儿茶素没食子酸酯。儿茶素多酚已知能够抑制儿茶酚-O-甲基转移酶（降解去甲肾上腺素的酶），这可能是绿茶提取物通过表没食子儿茶素没食子酸酯有效刺激产热以增强和延长交感神经对产热的刺激作用的一个解释。了解绿茶的表没食子儿茶素没食子酸酯产生的产热诱导体重减轻及其抑制儿茶酚-O-甲基转移酶 的能力，对于健康益处以及延长去甲肾上腺素在突触间隙中的作用非常重要。
