Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibañez, 15 46010 Valencia, Spain.
Oxid Med Cell Longev. 2020 Aug 6;2020:2097096. doi: 10.1155/2020/2097096. eCollection 2020.
Endothelial dysfunction tends to be the initial indicator in proinflammatory state and macro- and microvascular complications, such as atherosclerosis and cardiovascular diseases. It has been shown that certain compounds in diet can generate beneficial effects on cardiovascular disease due to its interactions with endothelial cells. Thus, this review is aimed at investigating whether certain polyphenols present in the Mediterranean diet, specifically catechin, quercetin, resveratrol, and urolithin, could exert positive effects on endothelial dysfunction. After analysis of numerous papers, we found that polyphenols aiding endothelial function is beneficial not only for patients with cardiovascular disease, diabetes, or endothelial dysfunction but for all people as it can improve the effects of aging on the endothelia. The additional benefit of these polyphenols on weight loss further improves health and lowers the risk of several diseases, including those caused by endothelial dysfunction. However, it is important to note that the dosages in the majorities of the studies mentioned in this review were of supplemental rather than nutritionally relevant quantities, and therefore, the recommended dosages are difficult to determine.
内皮功能障碍往往是促炎状态和大血管及微血管并发症（如动脉粥样硬化和心血管疾病）的初始指标。研究表明，饮食中的某些化合物可以通过与内皮细胞相互作用对心血管疾病产生有益影响。因此，本综述旨在研究地中海饮食中是否存在某些多酚，特别是儿茶素、槲皮素、白藜芦醇和乌索酸，是否对内皮功能障碍产生积极影响。在分析了大量论文后，我们发现，多酚有助于改善内皮功能不仅对心血管疾病、糖尿病或内皮功能障碍患者有益，而且对所有人都有益，因为它可以改善衰老对内皮的影响。这些多酚在减肥方面的额外益处进一步改善了健康状况，降低了多种疾病的风险，包括由内皮功能障碍引起的疾病。然而，值得注意的是，本综述中提到的大多数研究中的剂量都是补充剂而不是营养相关的量，因此，推荐剂量难以确定。
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