绵羊离体肋胸膜和膈胸膜电生理特性的比较。

Comparison of the electrophysiological properties of the sheep isolated costal and diaphragmatic parietal pleura.

作者信息

Zarogiannis Sotirios, Hatzoglou Chrissi, Stefanidis Ioannis, Ioannou Maria, Paraskeva Efrosini, Gourgoulianis Konstantinos, Molyvdas Paschalis-Adam

机构信息

Department of Physiology, Medical School, University of Thessaly, Larissa, Greece.

出版信息

Clin Exp Pharmacol Physiol. 2007 Jan-Feb;34(1-2):129-31. doi: 10.1111/j.1440-1681.2007.04549.x.

DOI:10.1111/j.1440-1681.2007.04549.x

Abstract

Pleural permeability may contribute to pleural fluid turnover. The transmesothelial resistance (R(TM)), is an established surrogate of mesothelial permeability. The aim of the present study was to compare the electrophysiological properties of costal and diaphragmatic parietal pleura. 2. Specimens of the parietal pleura were isolated from 12 adult sheep from the chest wall and the diaphragm. Electrophysiological measurements were conducted with the Ussing system. Specimens of the parietal pleura of both types (diaphragmatic and costal) were compared histologically and total protein content measurements were also made. 3. The R(TM) of the diaphragmatic parietal pleura was significantly higher than that of the costal parietal pleura throughout the experiment. The diaphragmatic parietal pleura contains more cuboidal cells than the costal parietal pleura and its protein content was higher, however this difference was not statistically significant. 4. The costal parietal pleura consists of a more 'leaky' mesothelium than the diaphragmatic pleura. The morphological differences between the two types of parietal pleura may underline the electrophysiological findings.

摘要

胸膜通透性可能有助于胸腔积液的周转。跨间皮电阻（R(TM)）是间皮通透性的既定替代指标。本研究的目的是比较肋胸膜和膈胸膜的电生理特性。2. 从12只成年绵羊的胸壁和膈肌分离出壁胸膜标本。使用尤斯灌流系统进行电生理测量。对两种类型（膈胸膜和肋胸膜）的壁胸膜标本进行组织学比较，并测量总蛋白含量。3. 在整个实验过程中，膈胸膜的R(TM)显著高于肋胸膜。膈胸膜比肋胸膜含有更多的立方形细胞，其蛋白含量更高，然而这种差异无统计学意义。4. 肋胸膜的间皮比膈胸膜更“渗漏”。两种类型壁胸膜之间的形态学差异可能是电生理结果的基础。