Department of Physiology, University of Thessaly Medical School, Mezourlo Hill, 41110 Larissa, Greece.
J Physiol Sci. 2009 Jul;59(4):335-9. doi: 10.1007/s12576-009-0042-x. Epub 2009 May 22.
The effect of dexamethasone on the transmesothelial electrical resistance (R(TM)) of sheep pleura was investigated by Ussing chamber experiments. Our results show that dexamethasone decreases the R(TM) of sheep pleurae, in part by stimulation of glucocorticoid receptors. This finding may be of importance in regard to the faster resolution of corticosteroid-treated pleural effusions.
采用 Ussing 室实验研究了地塞米松对绵羊胸膜跨上皮电阻 (R(TM))) 的影响。我们的结果表明，地塞米松通过刺激糖皮质激素受体降低绵羊胸膜的 R(TM)。这一发现对于解释糖皮质激素治疗后的胸腔积液更快消退可能具有重要意义。
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