Faculty of Science, Department of Pharmacy, National University of Singapore, Singapore.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Feb;26(2):145-51. doi: 10.1080/02652030802368757.
An unknown compound is detected and isolated from two herbal dietary supplements bought on the internet. The structure of the unknown compound is elucidated using ESI-MS/MS, NMR, UV and IR. The compound, named hydroxythiohomosildenafil, is identified as an analogue of sildenafil in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety, and a hydroxyethyl group instead of a methyl group is attached to the piperazinyl nitrogen. It is the first report of this compound being detected in herbal dietary supplements. The UV, IR and completely assigned NMR data of hydroxythiohomosildenafil is recorded.
从两种在互联网上购买的草药膳食补充剂中检测和分离出一种未知化合物。使用 ESI-MS/MS、NMR、UV 和 IR 阐明未知化合物的结构。该化合物被命名为羟基硫代 Homosildenafil，是一种 Sildenafil 的类似物，其中吡唑并嘧啶部分的氧原子被硫原子取代，而哌嗪氮上连接的是羟乙基而不是甲基。这是首次在草药膳食补充剂中检测到这种化合物。记录了羟基硫代 Homosildenafil 的 UV、IR 和完全分配的 NMR 数据。
