Seegmiller Adam C, Xu Yin, McKenna Robert W, Karandikar Nitin J
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9072, USA.
Am J Clin Pathol. 2007 Feb;127(2):176-81. doi: 10.1309/5EL22BH45PHUPM8P.
Some non-Hodgkin lymphomas show marked plasmacytic differentiation. In such cases, it may be difficult to differentiate these lymphoma from plasmacytoma or myeloma, especially with limited diagnostic material. However, there may be immunophenotypic differences in the plasma cells in these disorders that distinguish them. This study characterizes the immunophenotypes of neoplastic plasma cells in 41 cases of B-lineage non-Hodgkin lymphoma and compares them with those in plasma cell myeloma. We found that plasma cells in lymphoma were significantly more likely to express CD19, CD45, and surface immunoglobulin and less likely to express CD56 than those in myeloma. We further show that CD 19 and CD56 expression can be used reliably to distinguish these entities. Myeloma-associated osseous lesions and solitary plasmacytoma of bone showed myeloma-like immunophenotypes. However, some extramedullary plasmacytomas showed lymphoma-like phenotypes, suggesting that, in reality, they may represent non-Hodgkin lymphomas with extensive plasmacytic differentiation.
一些非霍奇金淋巴瘤表现出明显的浆细胞分化。在这种情况下，尤其是诊断材料有限时，可能难以将这些淋巴瘤与浆细胞瘤或骨髓瘤区分开来。然而，这些疾病中的浆细胞可能存在免疫表型差异，从而将它们区分开来。本研究对41例B细胞系非霍奇金淋巴瘤中肿瘤性浆细胞的免疫表型进行了特征分析，并将其与浆细胞骨髓瘤中的免疫表型进行了比较。我们发现，淋巴瘤中的浆细胞比骨髓瘤中的浆细胞更易表达CD19、CD45和表面免疫球蛋白，而表达CD56的可能性较小。我们进一步表明，CD19和CD56表达可可靠地用于区分这些实体。骨髓瘤相关的骨病变和骨孤立性浆细胞瘤表现出类似骨髓瘤的免疫表型。然而，一些髓外浆细胞瘤表现出类似淋巴瘤的表型，这表明实际上它们可能代表具有广泛浆细胞分化的非霍奇金淋巴瘤。
