Wynne Lyman C, Tienari Pekka, Sorri Anneli, Lahti Ilpo, Moring Juha, Wahlberg Karl-Erik
Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Fam Process. 2006 Dec;45(4):435-47. doi: 10.1111/j.1545-5300.2006.00181.x.
Previous reports from the Finnish Adoptive Family Study of Schizophrenia have documented significant interplay between genetics (G) and family rearing (E), leading to adoptee outcomes of schizophrenia spectrum disorders. Quantitative evidence for this interplay is significantly enhanced when both high genetic liability and severe environmental dysfunction are present. However, when either genetic liability is low or the rearing environment is healthy, the adoptees appear to be resiliently protected against a pathologic outcome. Nevertheless, exceptions to this pattern do occur. Six qualitative vignettes, together with quantitative measures and categorical diagnoses from the same families, illustrate how multiple methods partially confirm one another and also suggest where further exploration of gene-environment interaction is needed.
芬兰收养家庭精神分裂症研究先前的报告已证明基因（G）与家庭养育（E）之间存在显著的相互作用，导致被收养者出现精神分裂症谱系障碍的结果。当高遗传易感性和严重环境功能障碍同时存在时，这种相互作用的定量证据会显著增强。然而，当遗传易感性较低或养育环境健康时，被收养者似乎能得到有效保护，不易出现病理结果。尽管如此，这种模式也有例外情况。六个定性案例，连同来自同一家庭的定量测量和分类诊断，说明了多种方法如何相互部分证实，同时也指出了在哪些方面需要进一步探索基因-环境相互作用。
