St-Onge Marie-Pierre, Claps Nancy, Wolper Carla, Heymsfield Steven B
New York Obesity Research Center, St Luke's/Roosevelt Hospital, New York, NY 10026, USA.
J Am Diet Assoc. 2007 Mar;107(3):500-5. doi: 10.1016/j.jada.2006.12.002.
The objective of this study was to determine whether a weight-loss diet high in soy-protein-rich foods leads to greater weight loss and reductions in waist circumference, fat mass, and cardiovascular disease risk factors than a control diet. Groups of overweight women (body mass index [calculated as kg/m(2)] of 28 to 33, aged 25 to 49 years) were counseled to decrease their caloric intake by 500 kcal/day for a period of 12 weeks; in addition, the soy-protein-rich group was counseled to consume 15 g soy protein/1,000 kcal daily. Soy-protein-rich foods were provided to subjects. Body weight, waist circumference, percent body fat, fat-free mass, lipids, glucose, and insulin were measured at repeated intervals. Forty-seven women completed the study. Both groups lost a similar amount of weight both when a completers only (-3.18%+/-0.63% vs -4.04%+/-0.95% for soy-protein-rich and control diets, respectively) and a last-observation-carried-forward analysis (-1.93%+/-0.50% vs -2.50%+/-0.67%, for soy-protein-rich and control diets, respectively) were performed. There was no difference between groups in change in percent fat mass (-5.31%+/-1.50% for soy-protein-rich diet vs -3.94%+/-1.68% for control diet), percent fat-free mass, and waist circumference. There was no dietary assignment-by-group interaction on lipid, glucose, and insulin concentrations when analyses were done on completers only or on all subjects using a last-observation-carried-forward approach. Percent change in any of the biochemical parameters studied over the 12-week period was not significantly different between groups. Our results do not lend support to the emerging notion that soy-protein-rich foods could be considered potential functional foods for weight management, in the quantities consumed in this study.
本研究的目的是确定富含大豆蛋白的食物的减肥饮食是否比对照饮食能带来更大程度的体重减轻以及腰围、脂肪量和心血管疾病风险因素的降低。超重女性组（体重指数[以kg/m(2)计算]为28至33，年龄在25至49岁之间）被建议在12周内每天减少500千卡的热量摄入；此外，富含大豆蛋白的组被建议每天每1000千卡摄入15克大豆蛋白。向受试者提供富含大豆蛋白的食物。在不同时间间隔测量体重、腰围、体脂百分比、去脂体重、血脂、血糖和胰岛素。47名女性完成了研究。当仅对完成者进行分析时（富含大豆蛋白饮食组与对照组分别为-3.18%±0.63%和-4.04%±0.95%）以及进行末次观察结转分析时（富含大豆蛋白饮食组与对照组分别为-1.93%±0.50%和-2.50%±0.67%），两组减轻的体重相似。两组在脂肪量百分比变化（富含大豆蛋白饮食组为-5.31%±1.50%，对照组为-3.94%±1.68%）、去脂体重百分比和腰围方面没有差异。当仅对完成者或使用末次观察结转方法对所有受试者进行分析时，在血脂、血糖和胰岛素浓度方面不存在饮食分组交互作用。在12周期间，所研究的任何生化参数的百分比变化在两组之间没有显著差异。就本研究中所摄入的量而言，我们的结果并不支持以下新观点，即富含大豆蛋白的食物可被视为体重管理的潜在功能性食品。
