Xu Shun-Jun, Li Peng, Yang Liu, Zhang Mian, Wang Zheng-Tao
Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China.
Zhongguo Zhong Yao Za Zhi. 2006 Oct;31(20):1677-80.
To establish a HPLC fingerprint for quality evaluation of Cortex Moutan.
The HPLC chromatographic fingerprinting of 30 lots of Cortex Moutan was established and major peaks were identified by LC-MS and MS-MS.
The HPLC fingerprint of Cortex Moutan was established, showing 15 characteristic peaks. The areas of these peaks were found to complied with the following rule: paeonol > 1, 2, 3, 4, 6-penta-O-galloyl-glucos > methyl gallate > galloylpaeoniflorin > gallic acid > oxypaeoniflorin > other compounds.
The chromatographic fingerprinting of Cortex Moutan with high specificity can be used to control its quality and monitor lot to lot consistency.
建立牡丹皮的高效液相色谱指纹图谱用于其质量评价。
建立了30批牡丹皮的高效液相色谱指纹图谱，并通过液相色谱-质谱联用（LC-MS）和串联质谱（MS-MS）对主要峰进行了鉴定。
建立了牡丹皮的高效液相色谱指纹图谱，显示出15个特征峰。发现这些峰的面积符合以下规律：丹皮酚＞1,2,3,4,6-五没食子酰葡萄糖＞没食子酸甲酯＞没食子酰芍药苷＞没食子酸＞氧化芍药苷＞其他化合物。
牡丹皮具有高特异性的色谱指纹图谱可用于控制其质量并监测批次间的一致性。
