Hashimoto T, Tayama M, Miyazaki M, Murakawa K, Kuroda Y
Department of Pediatrics, University of Tokushima School of Medicine, Japan.
J Child Neurol. 1993 Apr;8(2):149-53. doi: 10.1177/088307389300800207.
Recent reports have suggested functional abnormalities of the brain stem in autistic children, and structural abnormalities have also been reported. We obtained magnetic resonance imaging (MRI) scans for 21 autistic children and compared them with 21 control MRI scans. The areas of the brain stem and cerebellar vermis were measured using midsagittal images. The brain stem and cerebellar vermis lobules VIII to X were found to be significantly smaller in autistic children. A positive correlation between the size of the brain stem and cerebellar vermis was observed in the autistic children. This correlation was not observed in the control children. This suggests that the size of the brain stem and cerebellar vermis are anatomically altered in autistic children and that growth of the brain stem and cerebellar vermis in autistic children is different from normal children.
近期报告显示自闭症儿童存在脑干功能异常，同时也有结构异常的报道。我们对21名自闭症儿童进行了磁共振成像（MRI）扫描，并将其与21名对照儿童的MRI扫描结果进行比较。利用正中矢状面图像测量脑干和小脑蚓部的面积。结果发现自闭症儿童的脑干和小脑蚓部VIII至X小叶明显较小。在自闭症儿童中观察到脑干大小与小脑蚓部之间存在正相关。而在对照儿童中未观察到这种相关性。这表明自闭症儿童的脑干和小脑蚓部在解剖结构上发生了改变，且自闭症儿童脑干和小脑蚓部的生长与正常儿童不同。
