Conforti Filomena, Statti Giancarlo Antonio, Tundis Rosa, Loizzo Monica Rosa, Menichini Francesco
Department of Pharmaceutical Sciences, University of Calabria, Rende (CS), Italy.
Phytother Res. 2007 May;21(5):427-33. doi: 10.1002/ptr.2077.
The present study showed for the first time the in vitro properties (antioxidant, hypoglycaemic and anticholinesterase) of Citrus medica L. cv. Diamante which belongs to the Rutaceae family. The n-hexane extract of Diamante citron peel is characterized by the presence of monoterpenes and sesquiterpenes. The most abundant constituents were two monoterpenes: limonene and gamma-terpinene. The extract showed significant antioxidant activity that was carried out using different assays (DPPH test, beta-carotene bleaching test and bovine brain peroxidation assay). Oxidative damage, caused by the action of free radicals, may initiate and promote the progression of a number of chronic diseases, including diabetes and Alzheimer's disease. Diamante citron peel extract showed hypoglycaemic activity and an anticholinesterase effect.
本研究首次展示了芸香科植物枸橼（Citrus medica L. cv. Diamante）的体外特性（抗氧化、降血糖和抗胆碱酯酶）。 Diamante香橼果皮的正己烷提取物的特征在于含有单萜和倍半萜。最丰富的成分是两种单萜：柠檬烯和γ-萜品烯。该提取物通过不同的测定方法（DPPH试验、β-胡萝卜素漂白试验和牛脑过氧化试验）显示出显著的抗氧化活性。由自由基作用引起的氧化损伤可能引发并促进包括糖尿病和阿尔茨海默病在内的多种慢性疾病的进展。Diamante香橼果皮提取物显示出降血糖活性和抗胆碱酯酶作用。
