Rogowski O, Shapira I, Shirom A, Melamed S, Toker S, Berliner S
Department of Medicine D and Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Heart. 2007 Aug;93(8):940-4. doi: 10.1136/hrt.2006.101949. Epub 2007 Jan 19.
To explore the possibility that increased resting heart rate (HR) is associated with a microinflammatory response. Such an association could explain, at least in part, the recently described worse cardiovascular prognosis in individuals with increased HR.
Concentrations of fibrinogen and high-sensitivity C-reactive protein, as well as the absolute number of polymorphonuclear leucocytes, were analysed in a cohort of 4553 apparently healthy men and in those with atherothrombotic risk factors.
Following adjustment for age and body mass index, lipid profile and cardiovascular risk factors, a significant (p<0.001) difference was noted between individuals in the first quintile of HR (< or =58 beats/min) and those in the fifth quintile (> or =79 beats/min) regarding all the above-mentioned inflammatory biomarkers, the respective mean values being 7.38 and 8.11 micromol/l, 1.12 and 1.61 mg/l, and 4.23 and 4.74 x 10(9)/l.
Resting HR is associated with a microinflammatory response in apparently healthy men and in those with atherothrombotic risk factors. Sympathetic activation might be a common factor explaining such an association. If confirmed in additional studies, this association might be a relevant target for therapeutic manipulations.
探讨静息心率（HR）升高与微炎症反应相关的可能性。这种关联至少可以部分解释最近所描述的HR升高个体心血管预后较差的情况。
对4553名貌似健康的男性以及有动脉粥样硬化血栓形成危险因素的人群进行队列研究，分析纤维蛋白原和高敏C反应蛋白的浓度以及多形核白细胞的绝对数量。
在对年龄、体重指数、血脂谱和心血管危险因素进行校正后，发现HR处于第一五分位数（≤58次/分钟）的个体与处于第五五分位数（≥79次/分钟）的个体在所有上述炎症生物标志物方面存在显著差异（p<0.001），各自的平均值分别为7.38和8.11微摩尔/升、1.12和1.61毫克/升、4.23和4.
