继发性“全身性”强直阵挛发作的广泛性如何？
How generalised are secondarily "generalised" tonic clonic seizures?
作者信息
Schindler Kaspar, Leung Howan, Lehnertz Klaus, Elger Christian E
机构信息
Klinik für Epileptologie, Sigmund-Freud-Str 25, D-53105 Bonn, Germany.
出版信息
J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):993-6. doi: 10.1136/jnnp.2006.108753. Epub 2007 Jan 19.
Abstract
In clinical practice, epileptic seizures with focal onset and subsequent generalised motor involvement are referred to as secondarily generalised seizures. The purpose of this study was to investigate the degree of electrophysiological generalisation in seizures that are clinically secondarily generalised. Intracranial EEG recordings of secondarily generalised tonic-clonic seizures were visually and quantitatively analysed for the presence of epileptiform activity. In 24 (26%) of 93 seizures recorded from 17 (27%) of 64 patients, intracranial EEG channels were found that never recorded epileptiform activity during secondarily generalised tonic-clonic seizures. Our results demonstrate that seizures that are secondarily generalised clinically are not always generalised electrophysiologically. This may have therapeutic implications.
摘要
在临床实践中，局灶性起病并随后出现全身性运动受累的癫痫发作被称为继发性全身性发作。本研究的目的是调查临床诊断为继发性全身性发作的癫痫发作的电生理泛化程度。对继发性全身性强直-阵挛发作的颅内脑电图记录进行了视觉和定量分析，以检测癫痫样活动的存在。在64例患者中的17例（27%）记录的93次发作中，有24次（26%）发作的颅内脑电图通道在继发性全身性强直-阵挛发作期间从未记录到癫痫样活动。我们的结果表明，临床诊断为继发性全身性发作的癫痫发作在电生理上并不总是全身性的。这可能具有治疗意义。
相似文献
1
How generalised are secondarily "generalised" tonic clonic seizures?继发性“全身性”强直阵挛发作的广泛性如何？
J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):993-6. doi: 10.1136/jnnp.2006.108753. Epub 2007 Jan 19.
2
Hippocampal involvement in secondarily generalised seizures of extrahippocampal origin.海马体在海马体外起源的继发性全身性癫痫发作中的作用。
J Neurol Neurosurg Psychiatry. 2008 Aug;79(8):924-9. doi: 10.1136/jnnp.2007.129387. Epub 2007 Dec 20.
3
Atypical "benign" partial epilepsy or pseudo-Lennox syndrome. Part I: symptomatology and long-term prognosis.非典型“良性”部分性癫痫或假性 Lennox 综合征。第一部分：症状学与长期预后。
Neuropediatrics. 2001 Feb;32(1):1-8. doi: 10.1055/s-2001-12216.
4
Clinical effects of topiramate against secondarily generalized tonic--clonic seizures.托吡酯治疗继发性全身性强直-阵挛性癫痫发作的临床疗效。
Epilepsy Res. 2002 Apr;49(2):121-30. doi: 10.1016/s0920-1211(02)00014-1.
5
Video-EEG evidence of lateralized clinical features in primary generalized epilepsy with tonic-clonic seizures.伴有强直阵挛发作的原发性全身性癫痫中临床特征偏侧化的视频脑电图证据。
Epileptic Disord. 2003 Sep;5(3):149-56.
6
Idiopathic generalised epilepsy in adults manifested by phantom absences, generalised tonic-clonic seizures, and frequent absence status.成人特发性全身性癫痫，表现为假性失神、全身性强直阵挛发作和频繁的失神持续状态。
J Neurol Neurosurg Psychiatry. 1997 Nov;63(5):622-7. doi: 10.1136/jnnp.63.5.622.
7
Clinical use of ictal SPECT in secondarily generalized tonic-clonic seizures.发作期单光子发射计算机断层扫描在继发性全身性强直-阵挛发作中的临床应用。
Brain. 2009 Aug;132(Pt 8):2102-13. doi: 10.1093/brain/awp027. Epub 2009 Apr 1.
8
18FDG-PET in epilepsies of infantile onset with pharmacoresistant generalised tonic-clonic seizures.18氟脱氧葡萄糖正电子发射断层扫描在婴儿期起病且药物难治性全面强直阵挛发作癫痫中的应用
Epilepsy Res. 2004 Jun;60(1):53-61. doi: 10.1016/j.eplepsyres.2004.05.006.
9
Side-to-side axial movements. Adding a new sign to the asymmetry of the clonic phase and asymmetric seizure termination in differentiating primary and secondarily generalised tonic-clonic seizures.左右轴向运动。在鉴别原发性和继发性全面性强直-阵挛性发作时，为阵挛期不对称性和发作终止不对称性增加一种新的体征。
Epileptic Disord. 2014 Mar;16(1):1-4. doi: 10.1684/epd.2014.0637.
10
EEG characterization of audiogenic seizures in the hamster strain GASH:Sal.听觉激发性癫痫在 GASH:Sal 品系仓鼠中的 EEG 特征
Epilepsy Res. 2013 Oct;106(3):318-25. doi: 10.1016/j.eplepsyres.2013.07.001. Epub 2013 Jul 31.
引用本文的文献
1
The Application of Deep Learning to Electroencephalograms, Magnetic Resonance Imaging, and Implants for the Detection of Epileptic Seizures: A Narrative Review.深度学习在脑电图、磁共振成像及植入物用于癫痫发作检测中的应用：一项叙述性综述
Cureus. 2023 Jul 25;15(7):e42460. doi: 10.7759/cureus.42460. eCollection 2023 Jul.
2
Brain lesion locations associated with secondary seizure generalization in tumors and strokes.与肿瘤和中风继发全身性发作相关的脑损伤部位。
Hum Brain Mapp. 2023 Jun 1;44(8):3136-3146. doi: 10.1002/hbm.26268. Epub 2023 Mar 27.
3
Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.局灶性意识障碍与强直-阵挛性发作中意识丧失的不同特征。
Brain. 2023 Jan 5;146(1):109-123. doi: 10.1093/brain/awac291.
4
White matter alterations in focal to bilateral tonic-clonic seizures.局灶性至双侧强直阵挛性发作中的白质改变。
Front Neurol. 2022 Sep 14;13:972590. doi: 10.3389/fneur.2022.972590. eCollection 2022.
5
Amplitude of Low-Frequency Fluctuation With Different Clinical Outcomes in Patients With Generalized Tonic-Clonic Seizures.全身强直阵挛性发作患者不同临床结局的低频波动幅度
Front Psychiatry. 2022 Apr 1;13:847366. doi: 10.3389/fpsyt.2022.847366. eCollection 2022.
6
Disrupted basal ganglia-thalamocortical loops in focal to bilateral tonic-clonic seizures.局灶性到双侧强直阵挛性发作中基底节-丘脑皮质环路的紊乱。
Brain. 2020 Jan 1;143(1):175-190. doi: 10.1093/brain/awz361.
7
[New classification of epileptic seizures : A critical evaluation of the changes].癫痫发作的新分类：对这些变化的批判性评估
Nervenarzt. 2020 Feb;91(2):114-121. doi: 10.1007/s00115-019-00800-3.
8
Parallel pathways of seizure generalization.癫痫发作泛化的并行途径。
Brain. 2019 Aug 1;142(8):2336-2351. doi: 10.1093/brain/awz170.
9
Absence of an Autonomic Sign Assists in the Diagnosis of Extratemporal Lobe Epilepsy Manifesting Generalized Convulsion with Retained Awareness.自主神经体征缺失有助于诊断表现为伴有意识保留的全身性惊厥的颞叶外癫痫。
Intern Med. 2019 Apr 15;58(8):1151-1155. doi: 10.2169/internalmedicine.1740-18. Epub 2018 Dec 18.
10
Resected Brain Tissue, Seizure Onset Zone and Quantitative EEG Measures: Towards Prediction of Post-Surgical Seizure Control.切除的脑组织、癫痫发作起始区和定量脑电图测量：迈向术后癫痫发作控制的预测
PLoS One. 2015 Oct 29;10(10):e0141023. doi: 10.1371/journal.pone.0141023. eCollection 2015.
本文引用的文献
1
Suppression of secondary generalization of limbic seizures by stimulation of subthalamic nucleus in rats.电刺激大鼠丘脑底核抑制边缘叶癫痫的继发性泛化
J Neurosurg. 2005 Jun;102(6):1122-9. doi: 10.3171/jns.2005.102.6.1122.
2
Are "generalized" seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absence.“全身性”癫痫发作真的是全身性的吗？失神发作时局部内侧额叶和额极放电的证据。
Epilepsia. 2004 Dec;45(12):1568-79. doi: 10.1111/j.0013-9580.2004.23204.x.
3
Terminology and classification of the cortical dysplasias.皮质发育异常的术语和分类
Neurology. 2004 Mar 23;62(6 Suppl 3):S2-8. doi: 10.1212/01.wnl.0000114507.30388.7e.
4
Interictal and ictal EEG activity in the basal ganglia: an SEEG study in patients with temporal lobe epilepsy.基底节区发作间期和发作期脑电图活动：一项颞叶癫痫患者的立体定向脑电图研究
Epilepsia. 2002 Mar;43(3):253-62. doi: 10.1046/j.1528-1157.2002.28001.x.
5
6
Using simulated neuronal cell models for detection of epileptic seizures in foramen ovale and scalp EEG.利用模拟神经元细胞模型检测卵圆孔和头皮脑电图中的癫痫发作。
Clin Neurophysiol. 2001 Jun;112(6):1006-17. doi: 10.1016/s1388-2457(01)00522-3.
7
Lateralizing value of asymmetric tonic limb posturing observed in secondarily generalized tonic-clonic seizures.继发性全面强直阵挛发作中观察到的不对称强直性肢体姿势的定侧价值。
Epilepsia. 2000 Apr;41(4):457-62. doi: 10.1111/j.1528-1157.2000.tb00189.x.
Zotero 插件