果蝇中转录调节效应的遗传定位和生化特性分析。
Genetic Localization and Biochemical Characterization of a TRANS-Acting Regulatory Effect in Drosophila.
机构信息
Department of Molecular, University of Georgia, Athens, Georgia 30602.
出版信息
Genetics. 1983 Sep;105(1):55-69. doi: 10.1093/genetics/105.1.55.
Abstract
A region-specific, trans-acting regulatory gene that alters in vivo protein levels of alpha-glycerophosphate dehydrogenase (alpha-GPDH) has been mapped to position 55.4 on the third chromosome of Drosophila melanogaster. The gene has been found to affect the in vivo stability of alpha-GPDH in adult thoracic tissue but has no effect on alpha-GPDH levels in the abdomen. Although no other thoracic proteins were found to be influenced by the locus, it appears to modify the level of one additional abdominal protein. The action of the gene over development and its possible mode of control are discussed.
摘要
一个位于果蝇第三号染色体 55.4 位置的、具有组织特异性和反式作用的调控基因，能够改变体内α-甘油磷酸脱氢酶（α-GPDH）的蛋白水平。该基因已被发现影响成年果蝇胸部组织中α-GPDH 的体内稳定性，但对腹部的α-GPDH 水平没有影响。虽然没有发现其他胸部蛋白受该基因座影响，但它似乎可以改变一种额外的腹部蛋白的水平。该基因在发育过程中的作用及其可能的控制模式正在讨论中。
相似文献
1
Genetic Localization and Biochemical Characterization of a TRANS-Acting Regulatory Effect in Drosophila.果蝇中转录调节效应的遗传定位和生化特性分析。
Genetics. 1983 Sep;105(1):55-69. doi: 10.1093/genetics/105.1.55.
2
Post-translational control of alcohol dehydrogenase levels in Drosophila melanogaster.黑腹果蝇中乙醇脱氢酶水平的翻译后调控
Genetics. 1987 Apr;115(4):693-9. doi: 10.1093/genetics/115.4.693.
3
Origin of alpha-glycerophosphate dehydrogenase isozymes in Drosophila melanogaster and their functional relationship in the alpha-glycerophosphate cycle.黑腹果蝇中α-甘油磷酸脱氢酶同工酶的起源及其在α-甘油磷酸循环中的功能关系。
Biochem Genet. 1977 Apr;15(3-4):235-51. doi: 10.1007/BF00484456.
4
The alpha glycerophosphate cycle in Drosophila melanogaster VI. structure and evolution of enzyme paralogs in the genus Drosophila.果蝇的α甘油磷酸循环 VI. 果蝇属中酶的旁系同源物的结构和进化。
J Hered. 2010 Mar-Apr;101(2):225-34. doi: 10.1093/jhered/esp111. Epub 2009 Dec 8.
5
A cytogenetic analysis of the chromosomal region surrounding the alpha-glycerophosphate dehydrogenase locus of Drosophila melanogaster.对黑腹果蝇α-甘油磷酸脱氢酶基因座周围染色体区域的细胞遗传学分析。
Genetics. 1983 Oct;105(2):371-86. doi: 10.1093/genetics/105.2.371.
6
A genetic analysis of the alpha-glycerophosphate oxidase locus in Drosophila melanogaster.黑腹果蝇中α-甘油磷酸氧化酶基因座的遗传分析。
Genetics. 1988 Nov;120(3):755-66. doi: 10.1093/genetics/120.3.755.
7
An independent non-linear latitudinal cline for the sn-glycerol-3-phosphate (alpha- Gpdh ) polymorphism of Drosophila melanogaster from eastern Australia.来自澳大利亚东部的黑腹果蝇sn-甘油-3-磷酸（α-Gpdh）多态性的独立非线性纬度渐变群。
Genet Res. 2006 Feb;87(1):13-21. doi: 10.1017/S0016672306007919. Epub 2006 Feb 10.
8
Genetic Localization and Action of Regulatory Genes and Elements for Tissue-Specific Expression of alpha-Amylase in DROSOPHILA MELANOGASTER.黑腹果蝇组织特异性α-淀粉酶表达的调控基因和元件的遗传定位与作用。
Genetics. 1986 Dec;114(4):1131-45. doi: 10.1093/genetics/114.4.1131.
9
Heat stability studies at the alpha-glycerophosphate dehydrogenase locus in populations of Drosophila melanogaster.黑腹果蝇群体中α-甘油磷酸脱氢酶基因座的热稳定性研究。
Biochem Genet. 1978 Aug;16(7-8):769-75. doi: 10.1007/BF00484734.
10
The characterization of alpha-glycerophosphate dehydrogenase mutants in Drosophila melanogaster.黑腹果蝇中α-甘油磷酸脱氢酶突变体的特性研究
Genetics. 1983 Oct;105(2):387-407. doi: 10.1093/genetics/105.2.387.
引用本文的文献
1
The Regulation of Aldehyde Oxidase in Imaginal Wing Discs of Drosophila Hybrids: Evidence for cis- and trans-Acting Control Elements.果蝇杂交翅盘中介醛氧化酶的调控：顺式和反式作用调控元件的证据。
Genetics. 1987 Feb;115(2):283-94. doi: 10.1093/genetics/115.2.283.
2
The influence of whole-arm trisomy on gene expression in Drosophila.整条臂三体对果蝇基因表达的影响。
Genetics. 1988 Jan;118(1):87-101. doi: 10.1093/genetics/118.1.87.
3
Regulation of Cat1 gene expression in the scutellum of maize during early sporophytic development.玉米早期孢子体发育过程中盾片中Cat1基因表达的调控
Proc Natl Acad Sci U S A. 1984 Aug;81(15):4903-7. doi: 10.1073/pnas.81.15.4903.
4
Genetic characterization of dipeptidase activity modifiers in Drosophila melanogaster from natural populations.自然种群中黑腹果蝇二肽酶活性调节剂的遗传特征分析。
Biochem Genet. 1988 Dec;26(11-12):783-803.
5
The effect of temperature on biochemical and molecular properties of Drosophila alcohol dehydrogenase.温度对果蝇乙醇脱氢酶生化及分子特性的影响
Biochem Genet. 1986 Dec;24(11-12):873-89. doi: 10.1007/BF00554526.
本文引用的文献
1
Quantitative genetic variation of enzyme activities in natural populations of Drosophila melanogaster.自然种群中黑腹果蝇酶活性的数量遗传变异。
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1073-7. doi: 10.1073/pnas.77.2.1073.
2
Structural analysis of adult and larval isozymes of sn-glycerol-3-phosphate dehydrogenase of Drosophila melanogaster.黑腹果蝇sn-甘油-3-磷酸脱氢酶成虫和幼虫同工酶的结构分析。
J Biol Chem. 1982 Jan 25;257(2):979-83.
3
Biochemical differences between products of the Adh locus in Drosophila.果蝇中乙醇脱氢酶（Adh）基因座产物之间的生化差异。
Genetics. 1980 Aug;95(4):1013-22. doi: 10.1093/genetics/95.4.1013.
4
Genetic regulation of enzyme activity in mammalian system by the alteration of the rates of enzyme degradation.通过改变酶降解速率对哺乳动物系统中酶活性进行的遗传调控。
Biochem Biophys Res Commun. 1967 Apr 20;27(2):119-24. doi: 10.1016/s0006-291x(67)80049-4.
5
Separate genes determining the structure and intracellular location of hepatic glucuronidase.决定肝脏葡萄糖醛酸酶结构和细胞内定位的不同基因。
Proc Natl Acad Sci U S A. 1967 Sep;58(3):938-45. doi: 10.1073/pnas.58.3.938.
6
Independent genetic control of the catalytic activity and the rate of degradation of catalase in mice.小鼠中过氧化氢酶催化活性和降解速率的独立遗传控制。
J Biol Chem. 1969 Sep 10;244(17):4649-58.
7
Regulation of enzyme activities in Drosophila. I. The detection of regulatory loci by gene dosage responses.果蝇中酶活性的调控。I. 通过基因剂量反应检测调控位点。
Genet Res. 1974 Aug;24(1):59-72. doi: 10.1017/s001667230001507x.
8
A model for genetic analysis of programmed gene expression as reflected in the development of membrane antigens.一种用于对程序性基因表达进行遗传分析的模型，该程序性基因表达在膜抗原的发育过程中得以体现。
Dev Biol. 1975 Nov;47(1):206-14. doi: 10.1016/0012-1606(75)90274-2.
9
A second gene affecting the sialylation of lysosomal alpha-mannosidase in mouse liver.影响小鼠肝脏溶酶体α-甘露糖苷酶唾液酸化的第二个基因。
Biochem Genet. 1978 Apr;16(3-4):247-60. doi: 10.1007/BF00484082.
10
Adaptive response due to changes in gene regulation: a study with Drosophila.基因调控变化引起的适应性反应：一项针对果蝇的研究。
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4562-6. doi: 10.1073/pnas.74.10.4562.
Zotero 插件