Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912.
Genetics. 1979 Aug;92(4):1141-52. doi: 10.1093/genetics/92.4.1141.
A type of intraspecific hybrid sterility, between two strains of Drosophila melanogaster, referred to as GD (gonadal dysgenesis) sterility, is observed when females from a type of strain called M are crossed with males from a second type called P. Absence of egg-laying is characteristic of female GD sterility and its manifestation is conditional on high developmental temperatures. Morphological and cytological studies of GD sterile females are described. These individuals were normal in body size and external appearance. No defects in sperm storage were observed. Both adult and larval ovaries were drastically reduced in size in comparison with control ovaries. This ovarian dysgenesis was sometimes unilateral, but more frequently it was bilateral, particularly in females developing at the highest test temperature. The ovarioles of dysgenic ovaries contained no vitellaria; the germaria lacked any cells resembling the cystocyte clusters of normal ovaries. It is concluded that sterility results from an early blockage in ovarian development, rather than from atrophy of previously developed structures. Possible mechanisms for this developmental arrest are discussed.
一种种内杂种不育性，发生在两个黑腹果蝇（Drosophila melanogaster）品系之间，称为 GD（性腺发育不良）不育性，当来自一种称为 M 的品系的雌性与来自第二种称为 P 的雄性交配时观察到。雌性 GD 不育的特征是不产卵，其表现取决于较高的发育温度。描述了 GD 不育雌性的形态学和细胞学研究。这些个体在体型和外观上正常。没有观察到精子储存的缺陷。与对照卵巢相比，GD 不育的成年和幼虫卵巢大小明显减小。这种卵巢发育不良有时是单侧的，但更常见的是双侧的，特别是在发育温度最高的雌性中。不育卵巢的卵原小管中没有卵黄体；生殖原细胞中没有任何类似于正常卵巢的囊原细胞簇的细胞。因此，不育是由于卵巢发育早期受阻所致，而不是先前发育的结构萎缩所致。讨论了这种发育停滞的可能机制。
