Department of Biology, The College of Wooster, Wooster, Ohio 44691.
Genetics. 1979 Aug;92(4):1153-71. doi: 10.1093/genetics/92.4.1153.
Assays of seven mutant stocks exposed a ten-fold range in spontaneous Minute mutation frequencies. Genetic analysis of the difference between the px (0.0006 Minutes) and bri (0.0042 Minutes) stocks revealed that each of these stocks lacks one of two complementary, autosomally transmitted, maternally expressed, dominant suppressors of a dominant 3-linked mutator present in the bri stock. Analysis of the ca; stw stock (0.0013 Minutes) with respect to the former two indicated the presence of the autosomal suppressor functions in addition to a maternally expressed, extrachromosomally transmitted, suppressor of a paternal chromosome-breaking mutator, which is also extra-chromosomally transmitted. The lesions induced by the two mutators in male carriers are probably different, but both kinds are subject to modification by the maternal suppressors soon after fertilization. The existence of these diverse controls of mutability is viewed as confirmation of Sturtevant's (1937) argument that natural selection invokes a variety of devices to minimize mutation rates while retaining mutational potential.
对七种突变株的分析显示，自发 Minute 突变频率的范围扩大了十倍。对 px（0.0006 分钟）和 bri（0.0042 分钟）品系之间差异的遗传分析表明，这两个品系都缺乏两个互补的、常染色体传递的、母系表达的显性抑制子之一，而 bri 品系中存在一个显性 3 连锁诱变剂。对 ca；stw 株（0.0013 分钟）与前两者的分析表明，除了一个母系表达的、染色体外传递的、对父染色体断裂诱变剂的抑制子之外，还存在常染色体抑制子功能，该抑制子也染色体外传递。雄性携带者中两种诱变剂诱导的损伤可能不同，但这两种诱变剂都在受精后不久受到母系抑制子的修饰。这些多样性的可变性控制的存在被视为斯特蒂文特（1937）论点的证实，即自然选择利用多种手段将突变率降到最低，同时保持突变潜力。
