果蝇变株抑制系统中的核质关系。
Nucleocytoplasmic relations in a mutator-suppressor system of Drosophila ananassae.
作者信息
Hinton C W
出版信息
Genetics. 1981 May;98(1):77-90. doi: 10.1093/genetics/98.1.77.
A partially characterized mutator-suppressor system, previously identified in the ca; stw stock of Drosophila ananassae, was shown to exist in the ca ancestral stock; it consists of a clastogenic mutator of sperm chromosomes and a suppressor that functions in the oöcyte soon after fertilization. Transmission of these components was monitored by Minute mutation frequencies produced by the progeny of recurrently backcrossed hybrid females derived from reciprocal outcrosses of the ca stock. In this way, the mutator was shown to be an extrachromosomally transmitted element whose propagation depends upon nuclear genes. Suppressivity was found to be determined by nuclear genes, some of which are expressed only after a delay of several generations. Neither the mutator nor its suppressor appear to be infectious. Measurement of dominant lethal frequencies showed that the suppressor is completely effective in repair of premutational lesions induced by the mutator. The properties of this mutator-suppressor system were compared with those of hybrid dysgenesis in Drosophila melanogaster.
一个部分特征化的诱变抑制系统，先前在拟果蝇的ca; stw品系中被鉴定出来，现已证明它存在于ca祖先品系中；它由精子染色体的致断裂诱变因子和受精后不久在卵母细胞中起作用的抑制因子组成。通过由ca品系正反交产生的反复回交杂种雌性后代产生的Minute突变频率来监测这些成分的传递。通过这种方式，诱变因子被证明是一种染色体外传递元件，其传播依赖于核基因。发现抑制性由核基因决定，其中一些核基因仅在几代延迟后才表达。诱变因子及其抑制因子似乎都没有传染性。显性致死频率的测量表明，抑制因子在修复由诱变因子诱导的突变前损伤方面是完全有效的。将这个诱变抑制系统的特性与黑腹果蝇杂种不育的特性进行了比较。
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