Martins Carla, Siqueira Walter Luiz, de Oliveira Elizabeth, Primo Laura Salignac de Souza Guimarães, Nicolau José
Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Brazil.
Spec Care Dentist. 2006 Sep-Oct;26(5):205-8. doi: 10.1111/j.1754-4505.2006.tb01439.x.
This study evaluated the flow rate and composition of whole saliva in patients with chronic renal failure undergoing hemodialysis. In the group on dialysis (RG) (n = 15), saliva was collected just prior to hemodialysis CT1) and at completion (T2), while in the healthy subjects (HG)(n = 15) saliva was collected at the same time of day as the pre-dialysis. Saliva samples were analyzed by inductively coupled argon plasma with atomic emission spectrometry. Significant differences were found in the flow rate, potassium, magnesium and phosphorus concentrations at the RG-T1 and HG (p < 0.05). Sodium concentration at RG-T1 and RG-T2 were higher than HG (p < 0.05). Total protein concentration was higher at RG-T1 than at the other two analyses. Salivary peroxidase activity at RG-T1 and RG-T2 was lower than at HG. Our findings suggest that in patients with chronic renal failure, the saliva is altered. Hemodialysis, however, seems to help control saliva composition and flow rate.
本研究评估了接受血液透析的慢性肾衰竭患者的全唾液流速和成分。在透析组（RG）（n = 15）中，在血液透析前（T1）和结束时（T2）采集唾液，而在健康受试者组（HG）（n = 15）中，在与透析前相同的时间采集唾液。唾液样本采用电感耦合氩等离子体原子发射光谱法进行分析。在RG-T1和HG之间，流速、钾、镁和磷浓度存在显著差异（p < 0.05）。RG-T1和RG-T2时的钠浓度高于HG（p < 0.05）。RG-T1时的总蛋白浓度高于其他两次分析时的浓度。RG-T1和RG-T2时的唾液过氧化物酶活性低于HG。我们的研究结果表明，慢性肾衰竭患者的唾液发生了改变。然而，血液透析似乎有助于控制唾液成分和流速。
