Borberg H, Kretschmer V, Godehardt E, Sojka G
Hämapherese der Medizinischen Universitätsklinik Köln.
Beitr Infusionsther. 1991;28:177-87.
The AS 104 separator provides for platelet yields in agreement with given standards. The number of undesired cells (leukocytes, erythrocytes) compares favorably with other technical separation systems. Concentrate volumes, total amount of ACD-A used, extracorporal blood volume and the reduction of donor blood cells are no challenge for the donor. The number of technical problems is not unusual for a new separation system entering into the first clinical evaluation. These data, as well as the deviation of yields, recommend further optimation. The technical optimation achieved so far and an expanded evaluation using statistical procedures permit an optimal, donor-independent (using variance analysis) or individual (using regression analysis) equilibration of the machine and permit the recognition of potential differences between different separators, centers or software versions, thus allowing the calculation of the number of runs needed to recognize differences from optimal standards.
AS 104 分离器所提供的血小板产量符合既定标准。与其他技术分离系统相比，不需要的细胞（白细胞、红细胞）数量具有优势。浓缩液体积、所用 ACD-A 的总量、体外血液量以及供体血细胞的减少对供体而言都不是问题。对于一个进入首次临床评估的新分离系统来说，技术问题的数量并不罕见。这些数据以及产量偏差表明需要进一步优化。到目前为止所实现的技术优化以及使用统计程序进行的扩展评估，能够实现机器的最佳、与供体无关（使用方差分析）或个性化（使用回归分析）平衡，并能够识别不同分离器、中心或软件版本之间的潜在差异，从而可以计算出识别与最佳标准差异所需的运行次数。
