Fv-1基因座对小鼠白血病病毒滴定的影响。
Effect of the Fv-1 locus on the titration of murine leukemia viruses.
作者信息
Jolicoeur P, Baltimore D
出版信息
J Virol. 1975 Dec;16(6):1593-8. doi: 10.1128/JVI.16.6.1593-1598.1975.
Abstract
Titration of N- and B-tropic murine leukemia viruses on sensitive and resistant cell lines has been studied by direct XC plaque assay and infective center assay. The titration of cloned B-tropic virus by infective center assay on BALB/3T3 (Fv-1b/b) and NIH/3T3 (Fv-1n/n) cells gave one-hit patterns, with 100-fold less infected NIH/3T3 cells than BALB/3T3 cells. The titration of B-tropic virus on DBA/2 cells (Fv-1n/n) was also a one-hit. The titration of a one-hit curve, and there were about 100-fold less infected BALB/3T3 cells than NIH/3T3 cells. Comparable results were obtained by titrating the cloned N-tropic virus on congenic SIM (Fv-1n/n) and SIM.R (Fv-1b/b) cells or the Gross N-tropic virus on BALB/3T3 cells. Therefore, our data indicate that the multiple-hit phenomenon described previously may not be an essential part of the Fv-1 gene restriction.
摘要
通过直接XC空斑试验和感染中心试验，研究了N-嗜性和B-嗜性鼠白血病病毒在敏感和抗性细胞系上的滴定。通过感染中心试验在BALB/3T3（Fv-1b/b）和NIH/3T3（Fv-1n/n）细胞上对克隆的B-嗜性病毒进行滴定，得到了单次打击模式，感染的NIH/3T3细胞比BALB/3T3细胞少100倍。在DBA/2细胞（Fv-1n/n）上对B-嗜性病毒进行滴定也是单次打击。对单次打击曲线进行滴定，感染的BALB/3T3细胞比NIH/3T3细胞少约100倍。通过在同基因的SIM（Fv-1n/n）和SIM.R（Fv-1b/b）细胞上滴定克隆的N-嗜性病毒，或在BALB/3T3细胞上滴定格罗斯N-嗜性病毒，也得到了类似的结果。因此，我们的数据表明，先前描述的多次打击现象可能不是Fv-1基因限制的必要组成部分。
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