在原代脐带来源的人类CD34+细胞中，HIV-1在病毒DNA整合之前就受到限制。
HIV-1 Is Restricted prior to Integration of Viral DNA in Primary Cord-Derived Human CD34+ Cells.
作者信息
Griffin Daniel O, Goff Stephen P
出版信息
J Virol. 2015 Aug;89(15):8096-100. doi: 10.1128/JVI.01044-15.
Abstract
Certain cells have the ability to block retroviral infection at specific stages of the viral cycle by the activities of well-characterized factors and transcriptional silencing machinery. Infection of murine stem cells (MSCs) by the murine leukemia viruses (MLVs) is profoundly blocked postintegration by transcriptional silencing. Here, we show that a dominant point of restriction of HIV-1 in human CD34+ cells is prior to integration of viral DNA and that HIV-1 restriction by human CD34+ cells is fundamentally different from MLV restriction by mouse cells.
摘要
某些细胞能够通过特征明确的因子和转录沉默机制的活动，在病毒周期的特定阶段阻断逆转录病毒感染。小鼠白血病病毒（MLV）对小鼠干细胞（MSC）的感染在整合后会因转录沉默而受到严重阻断。在此，我们表明，人类CD34+细胞中HIV-1的主要限制点在病毒DNA整合之前，并且人类CD34+细胞对HIV-1的限制与小鼠细胞对MLV的限制根本不同。
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