Monika Prakash, Chandraprabha Mathikere Naganna, Rangarajan Annapoorni, Waiker P Veena, Chidambara Murthy Kotamballi N
Department of Biotechnology, M.S. Ramaiah Institute of Technology, Bangalore, India.
Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India.
Front Nutr. 2022 Jan 20;8:791899. doi: 10.3389/fnut.2021.791899. eCollection 2021.
Although the word wound sounds like a simple injury to tissue, individual's health status and other inherent factors may make it very complicated. Hence, wound healing has gained major attention in the healthcare. The biology wound healing is precise and highly programmed, through phases of hemostasis, inflammation, proliferation and remodeling. Current options for wound healing which includes, use of anti-microbial agents, healing promoters along with application of herbal and natural products. However, there is no efficient evidence-based therapy available for specific chronic wounds that can result in definitive clinical outcomes. Under co-morbid conditions, chronic would poses numerous challenges. Use of Complementary and Alternative Medicines (CAMs) in health care sector is increasing and its applications in wound management remains like to "." Attempts have been made to understand the wound at the molecular level, mainly through the analysis of signature genes and the influence of several synthetic and natural molecules on these. We have outlined a review of challenges in chronic wound healing and the role of CAMs in chronic wound management. The main focus is on the applications and limitations of currently available treatment options for a non-healing wound and the best possible alternates to consider. This information generates broader knowledge on challenges in chronic wound healing, which can be further addressed using multidisciplinary approach and combination therapies.
虽然“伤口”这个词听起来像是对组织的简单损伤,但个体的健康状况和其他内在因素可能会使其变得非常复杂。因此,伤口愈合在医疗保健领域受到了广泛关注。伤口愈合的生物学过程精确且高度程序化,包括止血、炎症、增殖和重塑阶段。目前伤口愈合的选择包括使用抗菌剂、愈合促进剂以及应用草药和天然产品。然而,对于能产生明确临床结果的特定慢性伤口,尚无有效的循证疗法。在共病情况下,慢性伤口带来了诸多挑战。补充和替代医学(CAMs)在医疗保健领域的使用正在增加,其在伤口管理中的应用仍有待进一步探索。人们已尝试从分子层面理解伤口,主要通过分析特征基因以及几种合成和天然分子对这些基因的影响。我们概述了慢性伤口愈合中的挑战以及补充和替代医学在慢性伤口管理中的作用。主要关注的是目前针对不愈合伤口的治疗选择的应用和局限性以及可供考虑的最佳替代方案。这些信息能让人们更广泛地了解慢性伤口愈合中的挑战,可通过多学科方法和联合疗法进一步应对这些挑战。