Abrahamian H, Endler G, Exner M, Mauler H, Raith M, Endler L, Rumpold H, Gerdov M, Mannhalter C, Prager R, Irsigler K, Wagner O F
Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna, Austria.
Exp Clin Endocrinol Diabetes. 2007 Jan;115(1):38-41. doi: 10.1055/s-2007-948213.
Chronic inflammatory processes are thought to play a key role in the development of micro- and macrovascular complications in type 2 diabetes mellitus. An association between low -grade inflammation and type 2 diabetes has been described in some studies. We assayed the association of two frequent polymorphisms in proinflammatory cytokines: the interleukin 6 G(-174)C promoter polymorphism [IL-6G(-174)C], the exon 2 interleukin receptor antagonist insertion deletion polymorphism [IL1RA]) and serum CRP levels with the prevalence of diabetic nephropathy in patients suffering from type 2 diabetes mellitus.
A total of 141 patients with type 2 diabetes mellitus, with and without diabetic nephropathy was genotyped for the above mentioned polymorphisms: 66 with normoalbuminuria, 31 with microalbuminuria and 44 with macroalbuminuria. CRP levels were analysed by a high sensitivity - immunnephelometric assay.
While a significant association be-tween macroalbuminuria and CRP could be observed (p<0,015), no associations were found between IL-6G(-174)C or IL1RA genotype and any stage of nephropathy. CRP-levels were similar in the 3 different IL-6G(-174)C genotypes as well as in the 2 IL1RA genotypes.
In type 2 diabetic subjects elevated CRP levels are associated with an increased prevalence of albuminuria. The two investigated proinflammatory polymorphisms do not seem to contribute to initiation of nephropathy in type 2 diabetic patients but we cannot exclude effects of these polymorphisms on course of nephropathy.
慢性炎症过程被认为在2型糖尿病微血管和大血管并发症的发生发展中起关键作用。一些研究已经描述了低度炎症与2型糖尿病之间的关联。我们检测了促炎细胞因子中两种常见多态性（白细胞介素6 G（-174）C启动子多态性[IL-6G（-174）C]、外显子2白细胞介素受体拮抗剂插入缺失多态性[IL1RA]）以及血清CRP水平与2型糖尿病患者糖尿病肾病患病率之间的关联。
总共141例2型糖尿病患者，有或无糖尿病肾病，对上述多态性进行基因分型：66例正常白蛋白尿患者、31例微量白蛋白尿患者和44例大量白蛋白尿患者。通过高敏免疫比浊法分析CRP水平。
虽然可以观察到大量白蛋白尿与CRP之间存在显著关联（p<0.015），但未发现IL-6G（-174）C或IL1RA基因型与任何肾病阶段之间存在关联。3种不同的IL-6G（-174）C基因型以及2种IL1RA基因型中的CRP水平相似。
在2型糖尿病患者中，CRP水平升高与白蛋白尿患病率增加相关。所研究的两种促炎多态性似乎对2型糖尿病患者肾病的起始没有影响，但我们不能排除这些多态性对肾病病程的影响。
