Menter A, Black-Noller G, Riendeau L A, Monti K L
Division of Dermatology, Baylor University Medical Center, Dallas, TX 75246, USA.
J Am Acad Dermatol. 1997 Jul;37(1):96-100. doi: 10.1016/s0190-9622(97)70218-4.
Surgical procedures used to remove genital warts (cryotherapy, electrodesiccation) are painful. Attempts to reduce the discomfort of surgery by prior lidocaine infiltration anesthesia are compromised by the pain of the infiltration.
Our purpose was to determine the efficacy of topically applied lidocaine/prilocaine cream to reduce the pain of lidocaine infiltration and the pain associated with cryotherapy to remove genital warts.
Men, scheduled for removal of genital warts by cryotherapy, were randomly selected to receive one of three treatments: (1) lidocaine/prilocaine cream application, (2) 1% lidocaine infiltration, and (3) lidocaine/prilocaine cream application followed by infiltration of 1% lidocaine.
Application of lidocaine/prilocaine cream for 15 minutes markedly reduced the pain of lidocaine infiltration. The combination of lidocaine/prilocaine cream followed by infiltration of 1% lidocaine gave greater pain relief from the cryotherapy than did either anesthetic alone.
The application of lidocaine/prilocaine cream as an adjunct to lidocaine infiltration reduced the pain of infiltration and the pain associated with cryotherapy for the removal of genital warts.
用于去除尖锐湿疣的外科手术（冷冻疗法、电干燥法）很痛苦。试图通过事先进行利多卡因浸润麻醉来减轻手术不适，但却因浸润时的疼痛而受到影响。
我们的目的是确定局部应用利多卡因/丙胺卡因乳膏减轻利多卡因浸润疼痛以及与冷冻疗法去除尖锐湿疣相关疼痛的疗效。
计划通过冷冻疗法去除尖锐湿疣的男性被随机选择接受三种治疗之一：（1）应用利多卡因/丙胺卡因乳膏；（2）1%利多卡因浸润；（3）应用利多卡因/丙胺卡因乳膏后再进行1%利多卡因浸润。
应用利多卡因/丙胺卡因乳膏15分钟可显著减轻利多卡因浸润的疼痛。利多卡因/丙胺卡因乳膏联合1%利多卡因浸润比单独使用任何一种麻醉剂在冷冻疗法中能提供更大的疼痛缓解。
应用利多卡因/丙胺卡因乳膏作为利多卡因浸润的辅助手段，可减轻浸润疼痛以及与冷冻疗法去除尖锐湿疣相关的疼痛。
