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脉孢菌的昼夜节律性：环磷酸腺苷磷酸二酯酶抑制剂对其的改变

Circadian periodicity a neurospora: alteration by inhibitors of cyclic AMP phosphodiesterase.

作者信息

Feldman J F

出版信息

Science. 1975 Nov 21;190(4216):789-90. doi: 10.1126/science.173018.

DOI:10.1126/science.173018
PMID:173018
Abstract

Three methyl xanthine inhibitors of adenosine 3',5'-monophosphate phosphodiesterase-theophylline, aminophyline, and caffeine-lengthen the period of the circadian conidiation rhythm of Neurospora. The effect are seen in wild-type strains and in three mutant strains with genetically altered period lengths. These results suggest the possible involvement of adenosine 3', 5'-monophosphate in the control of circadian rhythmicity.

摘要

三种抑制腺苷3',5'-单磷酸磷酸二酯酶的甲基黄嘌呤——茶碱、氨茶碱和咖啡因——延长了粗糙脉孢菌昼夜产孢节律的周期。在野生型菌株以及三种周期长度发生基因改变的突变菌株中都观察到了这种效应。这些结果表明腺苷3',5'-单磷酸可能参与了昼夜节律的调控。

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