三聚偏磷酸钠交联多糖的高分辨率核磁共振光谱研究：反应机理的一种推测
High-resolution nuclear magnetic resonance spectroscopy studies of polysaccharides crosslinked by sodium trimetaphosphate: a proposal for the reaction mechanism.
作者信息
Lack Stéphane, Dulong Virginie, Picton Luc, Le Cerf Didier, Condamine Eric
机构信息
UMR 6522, CNRS-Université de Rouen, Laboratoire Polymères, Biopolymères et Membranes, F-76821 Mont Saint Aignan, France.
出版信息
Carbohydr Res. 2007 May 21;342(7):943-53. doi: 10.1016/j.carres.2007.01.011. Epub 2007 Jan 26.
An NMR spectroscopy study ((31)P, (1)H, (13)C) of the postulated crosslinking mechanism of sodium trimetaphosphate (STMP) on polysaccharides is reported using methyl alpha-D-glucopyranoside as a model. In a first step, reaction of STMP with Glc-OMe gives grafted sodium tripolyphosphate (STPP(g)). On the one hand, STTP(g) can react with a second alcohol functionality to give a crosslinked monophosphate. On the other hand, a monophosphate (grafted phosphate) could be obtained by alkaline degradation of STPP(g). NMR spectroscopy allows to detect the various species formed and to obtain the crosslinking density of STMP-polysaccharides hydrogels.
报道了一项以α-D-甲基吡喃葡萄糖苷为模型，对三聚磷酸钠（STMP）与多糖交联机理进行的核磁共振光谱研究（³¹P、¹H、¹³C）。第一步，STMP与葡萄糖甲苷（Glc-OMe）反应生成接枝三聚磷酸钠（STPP(g)）。一方面，STPP(g)可与第二个醇官能团反应生成交联单磷酸盐。另一方面，单磷酸盐（接枝磷酸盐）可通过STPP(g)的碱性降解获得。核磁共振光谱能够检测形成的各种物质，并得到STMP-多糖水凝胶的交联密度。
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