Kiratli Hayyam, Kocabeyoğlu Sibel, Bilgiç Sevgül
Hacettepe University School of Medicine, Department of Ophthalmology, Ankara, Turkey.
J AAPOS. 2007 Aug;11(4):404-5. doi: 10.1016/j.jaapos.2006.11.005. Epub 2007 Feb 15.
Sub-Tenon or subconjunctival administration of carboplatin is used to consolidate tumor regression by achieving high intraocular concentrations, without incurring systemic toxicity, in selected patients with intraocular retinoblastoma. Mild transient periocular edema is a common side effect of this treatment. We describe four patients with severe local soft-tissue toxic reaction mimicking preseptal cellulitis following subtenon carboplatin injections. The development of this complication after injecting through the inferior conjunctiva and unexpectedly severe signs are the unusual features of these patients. We did not encounter this complication after injections through the superior conjunctiva in 22 other patients using the same technique and identical drug dosage.
对于选定的眼内视网膜母细胞瘤患者，采用卡铂的球后或结膜下给药方式，通过实现高眼内浓度来巩固肿瘤消退，且不会产生全身毒性。轻度短暂的眼周水肿是这种治疗的常见副作用。我们描述了4例在球后注射卡铂后出现类似眶隔前蜂窝织炎的严重局部软组织毒性反应的患者。经下结膜注射后出现这种并发症以及意外严重的体征是这些患者的不寻常特征。在使用相同技术和相同药物剂量的另外22例患者中，经上结膜注射后未出现这种并发症。
