Ng Samuel Yao-Ming, Yoshida Toshimi, Georgopoulos Katia
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Curr Opin Immunol. 2007 Apr;19(2):116-22. doi: 10.1016/j.coi.2007.02.014. Epub 2007 Feb 20.
Hematopoiesis is the developmental process by which all blood and immune cells are generated. A decade-old scheme has supported an early and complete separation of the erythro-myeloid from the lymphoid lineages. Recent advances have re-drawn this map, separating lymphoid and myeloid from erythroid programs early in development. Subsequently, the fate restriction of both the lympho-myeloid and the erythro-megakaryocyte progenitors is dependent on Ikaros and its associated chromatin regulators. Genetic studies of this family of nuclear factors are now providing unique insight into the functional molecular signatures that bestow plasticity to the hematopoietic stem cell and its early progeny.
造血作用是生成所有血细胞和免疫细胞的发育过程。一个十年前的理论支持红细胞 - 髓细胞系与淋巴细胞系早期完全分离。最近的进展重新绘制了这一图谱，在发育早期将淋巴细胞系和髓细胞系与红细胞生成程序分离。随后，淋巴细胞 - 髓细胞系和红细胞 - 巨核细胞祖细胞的命运限制取决于IKAROS及其相关的染色质调节因子。对这一核因子家族的遗传学研究现在为赋予造血干细胞及其早期后代可塑性的功能分子特征提供了独特的见解。
