GB病毒C包膜2糖蛋白对HIV进入的抑制作用
HIV entry inhibition by the envelope 2 glycoprotein of GB virus C.
作者信息
Jung Susan, Eichenmüller Melanie, Donhauser Norbert, Neipel Frank, Engel Alfred M, Hess Georg, Fleckenstein Bernhard, Reil Heide
机构信息
Institute of Clinical and Molecular Virology, University Hospital of the Friedrich-Alexander-Universität, Erlangen-Nuremberg, Germany.
出版信息
AIDS. 2007 Mar 12;21(5):645-7. doi: 10.1097/QAD.0b013e32803277c7.
Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the in-vitro expression of GBV-C E1/E2 encoding RNA.
流行病学研究表明，丙型肝炎病毒（GBV-C）长期病毒血症与改善的HIV疾病进展之间存在关联。我们已经提供证据表明，GBV-C的单一蛋白，即糖蛋白E2，会干扰X4和R5嗜性HIV毒株的早期HIV复制步骤。用抗E2抗体进行预孵育可特异性消除这种抑制作用。通过体外表达编码GBV-C E1/E2的RNA证实了结果。
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