Jatoi Aminah, Burch Patrick, Hillman David, Vanyo Joanne M, Dakhil Shaker, Nikcevich Daniel, Rowland Kendrith, Morton Roscoe, Flynn Patrick J, Young Charles, Tan Winston
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Urology. 2007 Feb;69(2):289-94. doi: 10.1016/j.urology.2006.10.019.
Tomatoes are rich in lycopene. This study explored the efficacy of a lycopene-rich tomato product in androgen-independent prostate cancer and the reasons patients participated in an "alternative medicine" study.
This Phase II study evaluated 46 patients with androgen-independent prostate cancer. All were asymptomatic and had serum prostate-specific antigen elevation despite hormonal manipulation. All patients completed a questionnaire on their motivations for enrolling in an "alternative medicine" study. Patients were prescribed a lycopene-rich tomato supplement at a lycopene dose of 15 mg twice daily.
One patient manifested a tumor response with a 50% or greater confirmed decline in serum prostate-specific antigen level, yielding a response rate of 2%. Lycopene was well tolerated, but 1 patient died of a cancer-related hemorrhage, and 1 had grade 4 diarrhea. Grade 1 or 2 events included diarrhea in 18, nausea in 12, abdominal distension in 8, flatulence in 2, vomiting in 2, anorexia in 1, and dyspepsia in 1. The reasons for entering the trial are discussed and were overall positive.
Lycopene, as prescribed in our study, did not appear effective for androgen-independent prostate cancer. The patients' reasons for enrolling in this trial were positive and realistic.
番茄富含番茄红素。本研究探讨了一种富含番茄红素的番茄制品对雄激素非依赖性前列腺癌的疗效以及患者参与“替代医学”研究的原因。
这项II期研究评估了46例雄激素非依赖性前列腺癌患者。所有患者均无症状，尽管进行了激素治疗，但血清前列腺特异性抗原仍升高。所有患者均完成了一份关于其参与“替代医学”研究动机的问卷。患者被开了一种富含番茄红素的番茄补充剂，番茄红素剂量为每日两次，每次15毫克。
1例患者出现肿瘤反应，血清前列腺特异性抗原水平确认下降50%或更多，有效率为2%。番茄红素耐受性良好，但1例患者死于癌症相关出血，1例出现4级腹泻。1级或2级事件包括18例腹泻、12例恶心、8例腹胀、2例肠胃气胀、2例呕吐、1例厌食和1例消化不良。讨论了进入试验的原因，总体是积极的。
在我们的研究中，番茄红素对雄激素非依赖性前列腺癌似乎无效。患者参与该试验的原因是积极且现实的。
