Wang Zack Z, Au Patrick, Chen Tong, Shao Ying, Daheron Laurence M, Bai Hao, Arzigian Melanie, Fukumura Dai, Jain Rakesh K, Scadden David T
Maine Medical Center Research Institute, Scarborough, Maine 04074, USA.
Nat Biotechnol. 2007 Mar;25(3):317-8. doi: 10.1038/nbt1287. Epub 2007 Feb 25.
We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.
我们描述了一种可扩展的二维方法，该方法避免了胚胎体中间体，将人胚胎干细胞（hES）分化为内皮细胞。将分化后的细胞移植到严重联合免疫缺陷（SCID）小鼠体内后，这些细胞形成了分支状血管，融入宿主循环系统，并作为血液管道发挥作用达150天。
