Snow J B
Ann Otol Rhinol Laryngol. 1975 Nov-Dec;84(6):817-26. doi: 10.1177/000348947508400614.
Seven children with carcinoma of the nasopharynx have been treated and followed for five years. In this group of patients there were no cranial nerve palsies or radiographic evidence of destruction of the base of the skull. Four of the seven patients are living and well. The development of lymphoepithelioma in two siblings is of great interest from an environmental and genetic point of view. The older sibling developed the clinical manifestations of the tumor at 12 years of age and four years later the younger sibling developed them at 14 years of age. The possible etiologic relationship of carcinoma of the nasopharynx to the Epstein-Barr virus is discussed. The good survival rate in these patients under 21 years of age suggests that the prognosis in carcinoma of the nasopharynx is better in the younger age group than in adults. The management of these patients illustrates that carcinoma of the nasopharynx should be managed as a regional rather than a systemic disease. Systemic drug therapy is sometimes advocated because of confusion over the name lymphoepithelioma on the assumption that these tumors are more related to lymphomas and lymphosarcomas than carcinomas. It is clear that lymphoepitheliomas should be managed as carcinomas.
七名鼻咽癌患儿接受了治疗并随访了五年。在这组患者中，没有出现颅神经麻痹，也没有影像学证据表明颅底受到破坏。七名患者中有四名仍健在且情况良好。从环境和遗传学角度来看，两名同胞兄妹患淋巴上皮瘤的情况非常有趣。年长的同胞兄妹在12岁时出现了肿瘤的临床表现，四年后，年幼的同胞兄妹在14岁时出现了这些症状。文中讨论了鼻咽癌与爱泼斯坦-巴尔病毒可能的病因关系。这些21岁以下患者的良好生存率表明，鼻咽癌在较年轻年龄组的预后比成年人更好。对这些患者的治疗表明，鼻咽癌应作为一种局部疾病而非全身性疾病来处理。有时提倡进行全身药物治疗，是因为对淋巴上皮瘤这个名称存在混淆，认为这些肿瘤与淋巴瘤和淋巴肉瘤的关系比与癌的关系更密切。显然，淋巴上皮瘤应作为癌来处理。
