Chandran Vinod, Bhella Sita, Schentag Catherine, Gladman Dafna D
Psoriatic Arthritis Program, University Health Network, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario, Canada M5T 2S8.
Ann Rheum Dis. 2007 Jul;66(7):936-9. doi: 10.1136/ard.2006.065763. Epub 2007 Feb 26.
Fatigue is an important symptom in psoriatic arthritis (PsA).
To determine the reliability and validity of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT fatigue) Scale in PsA.
Consecutive patients attending the PsA clinic were assessed with the FACIT fatigue Scale twice, 1 week apart. Patients were assessed clinically according to a standardised PsA clinic protocol. Internal consistency of the 13 items on the FACIT fatigue questionnaire was measured using Cronbach's alpha; test-retest reliability by the intraclass correlation coefficient (ICC), and validity by the correlation of the FACIT fatigue results with other fatigue measures and disease characteristics.
135 patients (80 men and 55 women, mean (SD) age 52 (13) years, mean (SD) disease duration 17 (10) years) participated. The mean FACIT fatigue score was 35.8 (12.4). Cronbach's alpha was 0.96. Repeat questionnaires were returned by 54% of patients. No difference in disease characteristics was observed between those who did and did not return the questionnaires. The ICC for first and repeat FACIT fatigue scores was 0.95. The correlation between the FACIT fatigue and modified Fatigue Severity Score was -0.79 (95% CI -0.85 to -0.72). FACIT fatigue scores were lower in patients with overwhelming fatigue and fibromyalgia than in those without (p<0.001). The FACIT fatigue was correlated with the actively inflamed joint count (-0.43, 95% CI -0.56 to -0.28, p<0.001), but not with the clinically damaged joint count (-0.06, 95% CI -0.23 to 0.11, p = 0.51).
The FACIT fatigue results were reproducible, and correlated with other fatigue measures as well as with disease activity in patients with PsA. Therefore, the FACIT fatigue is a reliable and valid instrument to measure fatigue in PsA.
疲劳是银屑病关节炎(PsA)的一个重要症状。
确定慢性病治疗功能评估-疲劳(FACIT疲劳)量表在PsA中的信度和效度。
连续就诊于PsA门诊的患者接受FACIT疲劳量表评估,两次评估间隔1周。根据标准化的PsA门诊方案对患者进行临床评估。使用Cronbach's α测量FACIT疲劳问卷13个条目的内部一致性;采用组内相关系数(ICC)评估重测信度,通过FACIT疲劳结果与其他疲劳测量指标及疾病特征的相关性评估效度。
135例患者(80例男性和55例女性,平均(标准差)年龄52(13)岁,平均(标准差)病程17(10)年)参与研究。FACIT疲劳量表平均得分为35.8(12.4)。Cronbach's α为0.96。54%的患者返回了重复问卷。返回问卷和未返回问卷的患者在疾病特征方面未观察到差异。首次和重复FACIT疲劳评分的ICC为0.95。FACIT疲劳量表得分与改良疲劳严重程度评分的相关性为-0.79(95%CI -0.85至-0.72)。有严重疲劳和纤维肌痛的患者FACIT疲劳量表得分低于无此情况的患者(p<0.001)。FACIT疲劳量表得分与活动性炎症关节计数相关(-0.43,95%CI -0.56至-0.28,p<0.001),但与临床受损关节计数无关(-0.06,95%CI -0.23至0.11,p = 0.51)。
FACIT疲劳量表结果具有可重复性,且与PsA患者的其他疲劳测量指标以及疾病活动相关。因此,FACIT疲劳量表是测量PsA患者疲劳的可靠且有效的工具。